4 Synapses, NT's, Receptors Flashcards
Define, compare and contrast Inhibitory post-synaptic potentials (IPSPs) and
excitatory post-synaptic potentials (EPSPs). Contrast the generation and
conduction of PSPs and APs
Lol
Contrast temporal and spatial summation and their effect on PSPs.
Lol
Compare and contrast the mechanisms for short and long term synaptic
potentiation and depression.
Lol
Define the characteristics of a neurotransmitter and list the 4 classic categories
Substances released by pre-synaptic cell classified by choline esters, biogenic amines, amino acids, gaseous transmitters, neuropeptides.
4 categories:
Compare the synthesis and degradation of the amino acid derived
neurotransmitters (catecholamines, serotonin, and melatonin).
Biogenic amines
Describe function and provide an example of GPCR and RTK type receptors.
It’s a G-protein coupled receptor and targets about 50% of drugs. Generates cAMP or IP3 secondary messengers.
EX: B1 and B2 adrenergic receptors are examples. B1=heart, cAMP in heart contracts. B2=smooth muscle, cAMP relaxes
Receptor tyrosine kinases start kinase cascade to change transcription.
Define the intracellular results of the Gs, Gi, Gq
Gs- stimulates AC, increases cAMP
Gi-inhibits AC, decreases cAMP
Gq- activates phospholipase C to make IP3 and DAG. (IP3 opens Ca2+ channels and DAG activates kinase cascade)
Which cell at RMP, opening of which ion channel would result in EPSP?
Chloride
Potassium
Water
Calcium
Calcium
Consider a cell at RMP, opening of which ion channel would result in an IPSP?
Potassium
Calcium
Water
Sodium
Potassium
Coupled GPCRs
(RTK) receptors. Define
Gq-M3
Gi-M2
Gs-B1, B2
Is calcium a second messenger?
Serotonin binds to a receptor and causes a change in membrane polarity, it’s a ___________ receptor and ____________ receptor
Yes
Metabotropic
Ionotropic
