4 - Repair & Regeneration of NS Flashcards
Motor cortisol representation: Monkey experiment
Neural representation of the digit expanded in the motor cortex at the expense of wrist representation.
TMS
Non-invasic technique to do similar motor mapping in humans.
Adaptation after stimulated injury (infarct): Animals in rehab group…
Gained distal limb representation at the expense of areas that represented proximal muscles pre-infarct.
Pre-infarct regions can be forced to represent the affected limb given rehab training.
How do peripheral nerves regenerate?
Extending growth cones along the path of damaged Schwann cells.
T/F. Motor nerves regenerate and form connections with ANY muscle fibers.
True. Facilitation control of prosthetics.
Why doesn’t neural regeneration in the CNS work so well?
Due to glial scaring, glial cells (astrocytes) invade injury site and prevent neuronal regrowth.
Do neural stem cells exist?
Yes, but there’s difficulty integrating into injured circuits.
Where does adult neurogenesis occur?
1) Olfactory bulb
2) Hippocampus
Is adult neurogenesis in non-mammal common?
Yes. Goldfish, songbirds.
Neural regeneration is difficult but what provides a potent neuroprotective effect?
Exercise!
Where does adult neurogenesis take place?
Lateral walls of lateral ventricle.
What do neural stem cells produce?
1) Neuroblasts (Glioblasts)
2) Transient amplifying cells
Where do neuroblasts migrate?
1) Along the rostral migratory stream to olfactory bulls along extracellular metric pathway
2) Short distance to the hippocampus
