4 - Peptides

Question 1

What is the most common non ribosomal peptide

Answer 1

Glutathione

Question 2

Peptones are derived from

Answer 2

Animal meat digested by enzymes

Question 3

Opioid peptides are Derived from digestion of food proteins such as

Answer 3

gluten, egg, and casein

Question 4

Vasopressin as also called

Answer 4

ADH

Question 5

Vasopressin is synthesized where

Answer 5

as precursor in hyopthalamus

Question 6

Vasopressin is stored where

Answer 6

Pituitary Gland

Question 7

Oxytocin effects are

Answer 7

(1) Social bonding and trust (2) Uterine contraction (3) Facilitates delivery of milk from glands

Question 8

Oxytocin receptors are what kind of receptors

Answer 8

G protein coupled receptors

Question 9

What do oxytocin receptors require

Answer 9

Mg+2 and cholesterol

Question 10

Where is glucagon made

Answer 10

Alpha cells of Islets of Langerhan

Question 11

Where is the hormone Secretin secreted

Answer 11

S cells of the duodenum in the crypts of Lieberkuhn

Question 12

What is the primary function of secretin

Answer 12

Regulate duodenal pH

Question 13

What does glutathione function as

Answer 13

reducing agent

Question 14

Oxidized dimeric form of glutathione has to be reduced back by enzyme

Answer 14

Glutathione reductase

Question 15

Which 3 amino

acids are found in glutathione?

Answer 15

Cysteine, Glutamic acid, and Glycine

Question 16

In type 1 DM what is also not produced along side insulin

Answer 16

C Peptide

Question 17

C Peptide binds to receptor on cell surface and
activates signal transduction pathways
that result in stimulation

Answer 17

Na+, K+- ATPase and endothelial nitric oxide

synthase (eNOS)

Question 18

C peptide replacement has been shown to

have some effect on

Answer 18

alleviating peripheral neuropathies and improving renal function

Question 19

Peptide bond has what type of character

Answer 19

partial double bond character

Question 20

Secondary structure of proteins are formed by

Answer 20

different regions of the sequence (1) Alpha helices and (2) Beta sheets

Question 21

Alpha helix is stabilized by

Answer 21

hydrogen bonds

Question 22

What can disrupt an alpha helix

Answer 22

(1) Proline (2) Charged AA (3) Bulky AA

Question 23

Tertiary structures are stabilized by

Answer 23

– Disulfide bonds
– Hydrogen bonds
– Hydrophobic interactions
– Ionic interactions

Question 24

Globin structure is a bundle of

Answer 24

8 helices

Question 25

Hemoglobin is built from

Answer 25

2 alpha and 2 beta chains

Question 26

In sickle cell, Glu 6 in the beta chain is mutated to

Answer 26

Valine

Question 27

Mutated form in sickle cell make what

Answer 27

hydrophobic patch on the surface

Question 28

The hydrophobic patch in sickle cell does what

Answer 28

promotes polymerization

Question 29

Kinetic barriers are overcome by

Answer 29

heat shock protein (chaperones)

Question 30

What are the factors affecting stability of proteins

Answer 30

Temp, pH, solvent characteristics, hydrophobicity

Question 31

In Prions what is the main component of infecting agents

Answer 31

PrPSc

Question 32

In Prions abnormal protein structure has

Answer 32

extensive beta sheet character