4 - Peptides Flashcards
What is the most common non ribosomal peptide
Glutathione
Peptones are derived from
Animal meat digested by enzymes
Opioid peptides are Derived from digestion of food proteins such as
gluten, egg, and casein
Vasopressin as also called
ADH
Vasopressin is synthesized where
as precursor in hyopthalamus
Vasopressin is stored where
Pituitary Gland
Oxytocin effects are
(1) Social bonding and trust (2) Uterine contraction (3) Facilitates delivery of milk from glands
Oxytocin receptors are what kind of receptors
G protein coupled receptors
What do oxytocin receptors require
Mg+2 and cholesterol
Where is glucagon made
Alpha cells of Islets of Langerhan
Where is the hormone Secretin secreted
S cells of the duodenum in the crypts of Lieberkuhn
What is the primary function of secretin
Regulate duodenal pH
What does glutathione function as
reducing agent
Oxidized dimeric form of glutathione has to be reduced back by enzyme
Glutathione reductase
Which 3 amino
acids are found in glutathione?
Cysteine, Glutamic acid, and Glycine
In type 1 DM what is also not produced along side insulin
C Peptide
C Peptide binds to receptor on cell surface and
activates signal transduction pathways
that result in stimulation
Na+, K+- ATPase and endothelial nitric oxide
synthase (eNOS)
C peptide replacement has been shown to
have some effect on
alleviating peripheral neuropathies and improving renal function
Peptide bond has what type of character
partial double bond character
Secondary structure of proteins are formed by
different regions of the sequence (1) Alpha helices and (2) Beta sheets
Alpha helix is stabilized by
hydrogen bonds
What can disrupt an alpha helix
(1) Proline (2) Charged AA (3) Bulky AA
Tertiary structures are stabilized by
– Disulfide bonds
– Hydrogen bonds
– Hydrophobic interactions
– Ionic interactions
Globin structure is a bundle of
8 helices
