4. Neoplasia I

Question 1

2 basic components of all tumors?

Answer 1

1. clonal neoplastic cells
2. reactive stroma made up of CT, BVs, and variable #’s of inflammatory cells

(ratio of neoplastic cells: stroma varies widely)

Question 2

malignant neoplasms of mesenchymal tissue?

Answer 2

sarcoma

Question 3

epithelial neoplasms benign vs malignant?

Answer 3

oma vs carcinoma

Question 4

tumors of striated muscles?

Answer 4

rhabdomyoma and rhabdomyosarcoma

Question 5

tumors of smooth muscle?

Answer 5

leiomyoma and leiomyosarcoma

Question 6

tumors of blood vessels

Answer 6

hemangioma vs angiosarcoma

Question 7

tumor of lymph vessels?

Answer 7

lymphangioma vs lymphangiosarcoma

Question 8

tumor of synovium?

Answer 8

synovial sarcoma

Question 9

tumor of mesothelium?

Answer 9

mesothelioma (malignant)

Question 10

tumor of brain coverings?

Answer 10

meningioma vs invasive meningioma

Question 11

bone tumor?

Answer 11

osteoma vs osteogenic sarcoma

Question 12

cartilage tumor?

Answer 12

chondroma vs chondrosarcoma

Question 13

renal tubular epithelium tumors?

Answer 13

renal tubular adenoma vs renal cell carcinoma

Question 14

liver cell tumors?

Answer 14

liver cell adenoma vs hepatocellular carcinoma

Question 15

tumors of urinary epithelium?

Answer 15

urothelial (transitional cell) papilloma vs transitional cell (urothelial) carcinoma

Question 16

pleomorphism

Answer 16

variation in cell size and shape

Question 17

anisocytosis

Answer 17

variable cell size

Question 18

anaplasia

Answer 18

extreme lack of differentiation with extreme nuclear abnormalities

Question 19

growth fraction

Answer 19

fraction of tumor cells in the replicative pool (measured by mitotic count of immunostain for cycling cells like Ki-67)

Question 20

tumor volume doubling time is variable how?

Answer 20

throughout tumor’s lifetime and between tissues

Question 21

a highly malignant tumor that is poorly differentiated has a (high/low) growth rate

Answer 21

high

Question 22

carcinoma in situ

Answer 22

full-thickness dysplasia