4- Methylprednisolone (Solu-medrol)

Question 1

Class

Answer 1

Corticosteroid

Question 2

Onset
Peak effect
Duration

Answer 2

Onset: 1-2 hours
Peak effect: varies
Duration: 8-24 hours

Question 3

MOA:

Answer 3

• highly potent synthetic glucocorticoid that suppresses acute and chronic inflammation
• potentiates vascular smooth muscle relaxation by beta adregenergic agonists

Question 4

Indications

Answer 4

Acute spinal cord trauma
Anaphylaxis
Bronchodilator for unresponsive asthma

Question 5

Contraindication

Answer 5

Premature infants
Systemic fungal infections
Use with caution with GI bleeding

Question 6

Adult dose

Answer 6

Acute spinal cord trauma: 30 mg/kg IV over 30 minutes
Followed by infusion of 5.4mg/kg/h
Asthma/COPD/anaphylaxis: 1-2 mg/kg IV

Question 7

Pediatric dose

Answer 7

Acute spinal cord trauma: 30 mg/kg IV over 30 minutes
Followed by infusion of 5.4mg/kg/h
Asthmaticus/anaphylaxis: 2 mg/kg dose IV/ IO/IM (60mg max)