3- Magnesium Sulfate

Question 1

Class

Answer 1

Electrolyte

Anti inflammatory

Question 2

Onset

Duration

Answer 2

Onset: immediate
Duration: 30 minutes

Question 3

MOA

Answer 3

• reduces striated muscle contractions
• blocks peripheral neuromuscular transmission by reducing acetylcholine release at myoneural junction
• manages seizures in toxemia of pregnancy
• induces uterine relaxation
• can cause bronchodilation after beta agonists and anticholinergics have been administered

Question 4

Indications

Answer 4

Seizures of eclampsia
Torsades De Pointes
Hypomagnesaemia
Ventricular fibrillation
Ventricular tachycardia that is refractory to amiodarone
Life threatening dysrhythmias due to digitalis toxicity

Question 5

Contraindication

Answer 5

Heart block

Myocardial damage

Question 6

Adult dose

Answer 6

Seizures of eclampsia:1-4g of 10% solution IV/IO over 3 minutes
Cardiac arrest due to hypomagnesaemia/torsades de pointes: 1-2g of 10% solution IV/IO over 5-20 minutes
Torsades de pointed with pulse: 1-2g in 50-100 ml of D5W (over 5-60 minutes). *follow with 0.5-1g/h IV (tirate to control torsades)

Question 7

Pediatric dose

Answer 7

Pulseless v tach with torsades de pointes: 25-50 mg/kg IV/IO bolus of 10% solution (max 2g)
Torsades de pointes with pulse /hypomagnesaemia: 25-50 mg/kg IV/IO of 10% solution over 10-20 minutes(max 2g)
Status asthmaticus: 25-50 mg/kg IV/IO of 10% solution over 15-30 minutes (max 2g)