4: Drug metabolism and renal excretion

Question 1

Most drugs leave the body in the ___.

Answer 1

urine

Question 2

In which fluid, associated with the liver, can drugs be exceted?

Answer 2

Bile

Question 3

Drug metabolism renders drugs (more / less) polar.

What is the advantage of this?

Answer 3

more polar

Polar ions aren’t absorbed very well, so the kidneys don’t absorb the metabolites and they can be excreted via the urine

Question 4

Metabolised drugs are usually (more / less) active than they were before.

Answer 4

less

Question 5

What is the main organ of drug metabolism?

Answer 5

Liver

Question 6

Which family of proteins works to metabolise most drugs in the liver?

Answer 6

CYP proteins

Cytochrome P450 family

Question 7

In the first step of drug metabolism, the ___ family of proteins ___ the drug.

Answer 7

CYP

oxidise

Question 8

Phase 2 of drug metabolism occurs in the ___. It involves the addition of reactive groups to the drug to render it (active / inactive).

Answer 8

liver

inactive

Question 9

What is the main organ of drug excretion?

Answer 9

Kidney

Question 10

renal excretion is totally out of my depth and i doubt it’s going to come up until next year