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SP 2016 > 4. Drug interactions > Flashcards

4. Drug interactions Flashcards

1
Q

pharmacodynamics affected by

A
  • ph of solution
  • lipid solubility
  • addition of vasoconstrictor
  • pka
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2
Q

Cause higher systemic concentrations of local anesthetic

A

1) propranolol - decrease hepatic clearance

2) cimetidine - inhibit hepatic metabolism

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3
Q

B1

A

aten, meto, acebut, beta, biso

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4
Q

non-selective Beta cause

A

hypertension and bradycardia

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5
Q

vasoconstrictor and antidepressant cause

A

increase BP and HR, not one reported problem

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6
Q

Tricyclics and SNRI

A

ESPT, ECPS

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7
Q

vasoconstrictor and MAO problems

A
  • no direct interaction

- Nardil, Parnate

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8
Q

vasoconstrictor other antidepressants

A
  • SSRI, adone, buproprion, mirtazapine

- no problem

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9
Q

vasoconstrictor and alpha blocker

A
  • osin, phenylthiazine, butyrophenone
  • hypotension and tachycardia
  • epinephrine reversal
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10
Q

BPH drugs

A

phenothiazine and butyrophenone (alpha blocker)

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11
Q

COMT inhibitor treat

A
  • Parkinsons
  • tolcapone, entacapone
  • problem with exagerated epi response
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12
Q

amount of endogenous epi/min in stress

A

0.28mg

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13
Q

NSAIDS and competition for plasma binding sites

A
  • sulfonylurea oral hypoglycemics (glip, gly, gli)
  • not metformin
  • warfarin (+bleeding)
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14
Q

NSAIDS and decrease renal blood flow and excretion

A
  • increase digoxin (CHF patient)

- increase lithium (not ASA)

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15
Q

NSAIDS and decrease renal blood flow, increase renal toxicity

A
  • cyclosporine (SNR)

- tacrolimus (PP)

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16
Q
  • NSAID recommended doses without GI history
A
  • naproxen 550mg bid
  • flurbiprophen 100mg bid
  • diflusanil 1g/500mgbid
17
Q
  • NSAID recommended doses with GI history
A
  • etodolac 400mg tid
  • celecoxib 200mg bid
  • meloxican 7.5/15mg qd
18
Q

Opioid and CNS depressant

A
  • xanax, excessive sedation
19
Q

Opioid and antihistamine

A
  • allegra, excessive sedation
20
Q

Opioid and anticholinergic

A
  • spiriva, constipation
21
Q

Opioid and antidiarrheal

A
  • immodium, constipation
22
Q

Opioid and antihypertensive

A
  • hypotension
23
Q

enzyme that activates opoids

A

CYP 2D6

24
Q

inhibits CYP 2D6

A
  • SSRI (prozac, zoloft)
  • buproprion
  • diltiazem
25
Q

problem with merperidine opoid

A
  • interacts with MAO inhibitor - severe hypertension
26
Q

macrolides

A
  • erythromycin and clarithromycin
27
Q

Drugs that compete with macrolids for p450

A
  • WDCDTCC
28
Q
  • digoxin and macrolide cause
A
  • CV problem and arrythmia
29
Q

antibiotic and coumadin

A
  • penicillin - decrease vit K

- metronidazole - decrease metabolism

30
Q

antibiotic with OC

A
  • rifampin
31
Q

tetracycline increases

A
  • lithium levels
32
Q

metronidazole with

A

ethanol causes severe nausea and vomiting

SP 2016 (2 decks)

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