4: Citric Acid Cycle

Question 1

Name the enzymes discussed in this section, the types of reactions they catalyze, and the cofactors and prosthetic groups they utilize as summarized in the table in section 10.

What are my 2 mnemonics for Krebs cycle?

Answer 1

See pg. 86

1) Remember: Cindy Is Irresistably Kinky So She Fucks More Often

2) Carlos Deflowers Hymens On a Daily Schedule
- Dehydration then Decarboxylation

Question 2

Describe where the different stages of respiration occur within the cell.

Answer 2

Glycolysis: glucose into pyruvate (in the cytosol)

Conversion of pyruvate into acetyl CoA = mitochondrial matrix space

Citric acid cycle = mitochondrial matrix

Oxidative phosphorylation = inner mitochondrial membrane

+36 ATP per 1 molecule of Glucose

Question 3

List the three main functions of the Citric Acid Cycle.

Answer 3

A. Converts a number of different fuels to a common mobile fuel (NADH). NADH is a reducing agent.

B. Serves as the final meeting place of nearly all oxidizable substrates.

C. Provides intermediates for biosynthesis.

Question 4

Explain how the mechanism of succinyl-CoA synthetase illustrates the Common
Intermediate Principle.

Answer 4

Important Feature: Illustrates the “Common Intermediate Principle” where E ~ P, a phosphohistidyl, is a product of the first reaction and a substrate for the second, thereby coupling an exergonic reaction to an endergonic reaction.