4. Bone: Structure and Function Flashcards

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1
Q

What is the composition of bone? (numbers)

A

67% Inorganic

33% Organic

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2
Q

What are the Non-Collagenous Proteins found in bone?

A
Bone Sialoprotein (BSP)
Osteopontin (OP)
Osteocalcin (OC)
Osteonectin (ON)
Matrix Extracellular Phosphoglycoprotein
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3
Q

What is the outer layer of bone called?

A

Compact (cortical) bone

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4
Q

what is in the inner cavity of bone? (2)

A

Marrow

Cancellous

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5
Q

What are 3 orgnaizational units of bone?

A

circumferential (outer ring)
Concentric (osteonic) lamellae
Interstitial lamellae

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6
Q

Where do you find cancellous bone?

A

at the ends of long bones

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7
Q

At cancellous bone what happens?

A

site of blood cell production

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8
Q

between inner surface of cancellous and compact bone you find what?

A

endosteum

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9
Q

where do Osteoblast arise from?

A

mesenchyme

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10
Q

How do osteoblasts communicate?

A

through gap junctions

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11
Q

Osteoblasts lay what?

A

Osteoid matrix

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12
Q

Large multi-nucleated cells are…. known as

A

osteoclasts

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13
Q

IL-1B and TNF-a activate what?

A

Osteoclasts

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14
Q

What is a key Marker for osteoclasts?

A

TRAP (Tartrate Resistant Acid Phosphatase)

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15
Q

what is it called between the howship’s lacunae and intact bone?

A

Lamina Limitans

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16
Q

RANK, RANKL and OPG is regulated by

A

Osteoblasts

17
Q

RANKL

A

Osteoblasts

18
Q

RANK

A

Osteoclasts

19
Q

What is produced by osteoblasts to bind to RANKL?

A

OPG (Osteoprotegerin)

20
Q

Where do you find endochondral bone formation?

A

long bones

21
Q

Where odyou fin intramembranous ossification

A

bone of the skull?