4. Bone: Structure and Function

Question 1

What is the composition of bone? (numbers)

Answer 1

67% Inorganic

33% Organic

Question 2

What are the Non-Collagenous Proteins found in bone?

Answer 2

Bone Sialoprotein (BSP)
Osteopontin (OP)
Osteocalcin (OC)
Osteonectin (ON)
Matrix Extracellular Phosphoglycoprotein

Question 3

What is the outer layer of bone called?

Answer 3

Compact (cortical) bone

Question 4

what is in the inner cavity of bone? (2)

Answer 4

Marrow

Cancellous

Question 5

What are 3 orgnaizational units of bone?

Answer 5

circumferential (outer ring)
Concentric (osteonic) lamellae
Interstitial lamellae

Question 6

Where do you find cancellous bone?

Answer 6

at the ends of long bones

Question 7

At cancellous bone what happens?

Answer 7

site of blood cell production

Question 8

between inner surface of cancellous and compact bone you find what?

Answer 8

endosteum

Question 9

where do Osteoblast arise from?

Answer 9

mesenchyme

Question 10

How do osteoblasts communicate?

Answer 10

through gap junctions

Question 11

Osteoblasts lay what?

Answer 11

Osteoid matrix

Question 12

Large multi-nucleated cells are…. known as

Answer 12

osteoclasts

Question 13

IL-1B and TNF-a activate what?

Answer 13

Osteoclasts

Question 14

What is a key Marker for osteoclasts?

Answer 14

TRAP (Tartrate Resistant Acid Phosphatase)

Question 15

what is it called between the howship’s lacunae and intact bone?

Answer 15

Lamina Limitans

Question 16

RANK, RANKL and OPG is regulated by

Answer 16

Osteoblasts

Question 17

RANKL

Answer 17

Osteoblasts

Question 18

RANK

Answer 18

Osteoclasts

Question 19

What is produced by osteoblasts to bind to RANKL?

Answer 19

OPG (Osteoprotegerin)

Question 20

Where do you find endochondral bone formation?

Answer 20

long bones

Question 21

Where odyou fin intramembranous ossification

Answer 21

bone of the skull?