4 - Applied basic science Flashcards

1
Q

Describe basic breathing mechanics.

A
  • inspiratory muscles contract
  • thoracic volume increases, thoracic pressure decreases
  • air pushes in along pressure gradient
  • expiration is passive
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2
Q

What is the difference between quiet versus forced breathing?

A
  • diaphragm contracts for quiet breathing
  • intercostal and accessory muscles are used for forced breathing
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3
Q

What is tidal volume?

A
  • volume of air inspired during quiet breathing
  • around 440ml
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4
Q

What is IRV?

A
  • inspiratory reserve volume
  • maximal inspiratory level
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5
Q

What is ERV?

A
  • expiratory reserve volume
  • resting expiratory level
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6
Q

What is RV?

A
  • residual volume
  • maximal expiratory volume
  • some air always remain within the lungs
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7
Q

What is the dead space?

A
  • also known as the conducting zone
  • trachea, bronchi, terminal bronchiole
  • not included in residual volume as no gas exchange occurs here
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8
Q

What is the respiratory zone?

A
  • region of gas exchange
  • respiratory bronchiole, alveolar duct, alveolar sac
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9
Q

What volume is the dead space?

A

150ml

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10
Q

What is the normal alveolar ventilation volume?

A

300ml

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11
Q

What is alveolar ventilation?

A
  • volume of fresh air entering alveoli
  • 150ml of air from dead space included from previous breath
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12
Q

Describe pulmonary gas exchange.

A
  • occurs between alveolar air and pulmonary capillary blood
  • gases move across wall by diffusion determined by the partial pressure gradient
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13
Q

Describe oxygen transport.

A
  • 97% attached to haemoglobin
  • 3% dissolved in plasma
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14
Q

How is CO2 transported in the blood?

A
  • erythrocytes
  • plasma
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15
Q

How is breathing controlled?

A
  • breathing muscles are skeletal (voluntary)
  • rhythm is generated from respiratory centres in brainstem and modified by sensory receptors
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16
Q

What causes hypoxic hypoxia?

A
  • not enough oxygen reaching alveoli
  • decreased oxygen diffusion into blood
17
Q

What causes anaemic hypoxia?

A

Decreased oxygen transport in blood due to low haemoglobin

18
Q

What causes stagnant hypoxia?

A

Decreased oxygen transport in blood due to low blood flow

19
Q

What causes cytotoxic hypoxia?

A

Decreased oxygen utilisation by cells

20
Q

What is cyanosis?

A
  • blue colouration of skin or mucosa due to increased presence of deoxygenated blood
  • can be central or peripheral
21
Q

What causes central cyanosis?

A

Hypoxic hypoxia

22
Q

What causes peripheral cyanosis?

A

Stagnant hypoxia

23
Q

What are the four chambers of the heart?

A
  • R atrium
  • R ventricle
  • L atrium
  • L ventricle
24
Q

What are the four valves of the heart?

A
  • tricuspid
  • pulmonary
  • mitral (bicuspid)
  • aortic
25
Q

Describe the conducting system of the heart.

A
  • SA node is the pacemaker for both atria
  • AV node delays the signal for the chambers to fill with blood
  • the purkinje fibres and bundle of his dissipate the signal through the muscles of the ventricles
26
Q

What does the P wave show?

A

Atrial depolarisation

27
Q

What does the QRS wave show?

A

Ventricular depolarisation (bundle of his)

28
Q

What does the T wave show?

A

Ventricular repolarisation

29
Q
A