[4] Aortic Stenosis Flashcards

1
Q

What happens when the left ventricle contracts?

A

It forces blood through the valve and into the aorta

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2
Q

What happens to the aortic valve when the left ventricle relaxes?

A

The aortic valve closes and prevents regurgitation

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3
Q

What occurs as a consequence of aortic valve stenosis?

A

The left ventricles must generate a higher pressure with each contraction to effectively move blood into the aorta. Initially, the LV generates this pressure with myocardial hypertrophy, however in later stages, the left ventricle dilates, the wall thins, and systolic function deteriorates

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4
Q

What are the risk factors for aortic stenosis?

A
  • Smoking
  • Hypertension
  • High cholesterol
  • Diabetes
  • Male gender
  • End-stage kidney disease
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5
Q

What are the causes of aortic valve stenosis?

A
  • Age related progressive calcification of aortic valve
  • Calcification of a congenital bicuspid aortic valve
  • Acute rheumatic fever
  • Faby disease
  • Systemic lupus erythematosus
  • Paget disaease
  • Hyperuricaemia
  • Infection
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6
Q

What do the symptoms of aortic valve stenosis depend on?

A

The degree of stenosis - most people with mild to moderate aortic stenosis don’t have symptoms, and symptoms usually present in individuals with severe aortic stenosis

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7
Q

What are the symptoms of aortic stenosis?

A
  • Loss of consciousness
  • Anginal chest pain
  • Shortness of breath on exertion
  • Nocturnal shortness of breath
  • Oedema
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8
Q

What is involved in the diagnosis of aortic stenosis?

A
  • Examination
  • ECG
  • Chest x-ray
  • Echocardiogram
  • Cardiac catheterisation
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9
Q

What are the examination findings in aortic stenosis?

A
  • Pale, sweaty general appearance
  • Increased heart rate
  • Slow-rising pulse
  • Pressure loaded, non-displaced apex beat
  • Thrill in aortic area
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10
Q

What might the ECG show in aortic stenosis?

A

Abnormal patterns on ECG might reflect a thickened heart muscle

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11
Q

What might the CXR show in aortic stenosis

A

Usually shows a normal heart shadow, however the aorta above the aortic valve is often dilated. Sometimes calcification of the aortic valve can be seen

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12
Q

What might the CXR show if heart failure is present with aortic stenosis?

A
  • Fluid in the lung tissue
  • Larger blood vessels in the upper lung regions
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13
Q

What does echocardiography show in aortic stenosis?

A

Thickened, calcified aortic valve which opens poorly

May show abnormal size and functioning of heart chambers

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14
Q

How can the Doppler technique be utilised in aortic stenosis?

A

To determine the pressure difference on either side of the aortic valve, and to estimate the aortic valve area

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15
Q

What happens in cardiac catheterisation in investigation of aortic valve stenosis?

A

Small catheters are advanced under x-ray guidance to the aortic valve and into the left ventricle. Simultaneous pressures are measured on both sides, and the rate of blood flow across the aortic valve can also be measured. Using this data, the aortic valve area can be calculated.

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16
Q

What is the normal aortic valve area?

A

3cm2

17
Q

At what aortic valve area do symptoms usually occur?

A

Less than 1cm2

18
Q

How are patients without symptoms, or patients with mild aortic stenosis, managed?

A

They can be observed until symptoms develop

19
Q

What aortic valve area is considered to be moderate aortic valve stenosis?

A

1.0-1.5cm2

20
Q

How are patients with moderate aortic stenosis managed?

A

Advise to avoid strenuous activity

21
Q

When is aortic valve replacement required?

A

When symptoms of chest pain, syncope, or shortness of breath appear

22
Q

What are the options for aortic valve replacements?

A
  • Bioprostheses, processed from pigs or cows
  • Mechanical prostheses
23
Q

What are the advantages of bioprostheses in aortic valve replacement?

A

Patients do not need life-long anticoagulation

24
Q

What are the disadvantages of bioprostheses in aortic valve replacement?

A
  • Less durable
  • Rapidly calcify, degenerate, and young patients
25
Q

Which patients are bioprostheses primarily used in aortic valve replacement?

A
  • Older patients
  • Those who cannot take blood thinners
26
Q

What are the advantages of mechanical prostheses in aortic valve replacement?

A

Extremely durable, can last from 20-40 years

27
Q

What are the disadvantages of mechanical prostheses in aortic valve replacement?

A

Requires life-long anticoagulation to reduce the risk of embolic stroke

28
Q

What happens in balloon valvuoplasty?

A

The aortic valve area can be opened or enlarged with a balloon catheter, which increases the aortic valve area slightly

29
Q

What is the purpose of balloon valvuoplasty?

A

It provides temporary improvement in patients with critical aortic stenosis

30
Q

What is the problem with ballon valvuloplasty?

A

Valves usually narrow again over a 6-18 month period, and therefore is only useful as a short-term measure to temporarily relieve symptoms

31
Q

Who is balloon valvuloplasty used in?

A

Patients who are not candidates for aortic valve replacement