4. Antifungal Drugs Flashcards
Classification of anti fungal based on MOA
483
On cell wall
Echinocandins
On cell membrane
AMB and nystatin
Inhibits ergosterol synthesis
Azoles
Inhibit squalene epoxide synthesis
Terbinafine
Acts on microtubules there inhibiting mitosis / division
Griseofulvin
Acts on DNA
Flucytosine
AMPHOTERACIN- B MOA :- ROA:- DOC for :- Side effects :-
483
AMB + KCL is given in combination why
AMB + preload 1-2 L of normal saline why
848
Nephrotoxicity is highest with :-
484
Combination for treatment of cryptococcal meningitis
484
Azoles
MOA :-
Types and examples :-
Spectrum:-
484
Fluconazole
DOC
Candida ( mucocutaneous candidiasis )
Coccidiodal meningitis
Itraconazole
DOC
Endemic mycosis
Sporotricosis
Tinea ( cruris and corporis )
Allergic broncopulmonary aspergillosis
DOC :-
Why itraconazole with it
485
Ketoconazole
Use :-
Important about ketoconazole :-
Use :-
485
Voriconazole
DOC
Invasive aspergillosis ( no response :- posaconazole ) Scedosporum Trichosporon
Posaconazole
Used as prophylaxis for :-
Use in :-
Mucormycosis
Prophylaxis for fungal inf in GVHD
Induction chemotherapy for leukaemia
Side effects of azoles :- Hair loss :- Gynacomastia :- CHF/ edema :- Voricanazole causes :-
486
Flucytosine MOA :- Terbinafine MOA :- Uses :- Side effect :- Oral :- max concentration in :- DOC for :- ( except )
486
Hepatotoxicity and SJ syndrome caused by :-
Flucytosine and terbinafine
Flucytosine function against 3C :-
Crypto coccus
Candida
Agent causing chromoblastomycosis
Griseofulvin MOA :- Oral :- max concentration in :- Only use of grisofulvin is :- Not for Side effects :-
486
Echinocandins MOA Examples :- Used for :- Prophylaxis Side effects :-
487
Tavaborole
MOA :-
Use :-
487
Nystatin :-
Natamycin :-
487
Tropical antifungal has no role in :-
Systemic fungal inf like
Sporotricosis
Chromoblastomycosis
