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Pharmacology > 4. Antifungal Drugs > Flashcards

4. Antifungal Drugs Flashcards

1
Q

Classification of anti fungal based on MOA

A

483

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2
Q

On cell wall

A

Echinocandins

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3
Q

On cell membrane

A

AMB and nystatin

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4
Q

Inhibits ergosterol synthesis

A

Azoles

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5
Q

Inhibit squalene epoxide synthesis

A

Terbinafine

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6
Q

Acts on microtubules there inhibiting mitosis / division

A

Griseofulvin

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7
Q

Acts on DNA

A

Flucytosine

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8
Q 
AMPHOTERACIN- B 
MOA :- 
ROA:- 
DOC for :- 
Side effects :-
A

483

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9
Q

AMB + KCL is given in combination why

AMB + preload 1-2 L of normal saline why

A

848

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10
Q

Nephrotoxicity is highest with :-

A

484

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11
Q

Combination for treatment of cryptococcal meningitis

A

484

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12
Q

Azoles
MOA :-
Types and examples :-
Spectrum:-

A

484

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13
Q

Fluconazole

DOC

A

Candida ( mucocutaneous candidiasis )

Coccidiodal meningitis

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14
Q

Itraconazole

DOC

A

Endemic mycosis
Sporotricosis
Tinea ( cruris and corporis )

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15
Q

Allergic broncopulmonary aspergillosis
DOC :-
Why itraconazole with it

A

485

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16
Q

Ketoconazole
Use :-
Important about ketoconazole :-
Use :-

A

485

17
Q

Voriconazole

DOC

A 
Invasive aspergillosis ( no response :- posaconazole ) 
Scedosporum 
Trichosporon
18
Q

Posaconazole
Used as prophylaxis for :-
Use in :-

A

Mucormycosis
Prophylaxis for fungal inf in GVHD
Induction chemotherapy for leukaemia

19
Q 
Side effects of azoles :- 
Hair loss :- 
Gynacomastia :- 
CHF/ edema :- 
Voricanazole causes :-
A

486

20
Q 
Flucytosine MOA :- 
Terbinafine MOA :- 
Uses :- 
Side effect :- 
Oral :- max concentration in :-
DOC for :- ( except )
A

486

21
Q

Hepatotoxicity and SJ syndrome caused by :-

A

Flucytosine and terbinafine

22
Q

Flucytosine function against 3C :-

A

Crypto coccus
Candida
Agent causing chromoblastomycosis

23
Q 
Griseofulvin 
MOA :- 
Oral :- max concentration in :- 
Only use of grisofulvin is :- 
Not for 
Side effects :-
A

486

24
Q 
Echinocandins 
MOA 
Examples :- 
Used for :- 
Prophylaxis 
Side effects :-
A

487

25
Q

Tavaborole
MOA :-
Use :-

A

487

26
Q

Nystatin :-

Natamycin :-

A

487

27
Q

Tropical antifungal has no role in :-

A

Systemic fungal inf like
Sporotricosis
Chromoblastomycosis

Pharmacology (4 decks)

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