4 - Analgesia Flashcards
What are the common analgesics prescribed from the dental practitioners formulary?
- aspirin
- ibuprofen
- diclofenac
- paracetamol
- dihydrocodeine
- carbamazepine
How are prostaglandins produced?
- trauma/infection lead to breakdown of membrane phospholipids which produces arachidonic acid
- arachidonic acid breaks down to prostaglandins
What is the role of prostaglandins in pain?
- sensitise other tissues to inflammatory products which results in pain
- do not cause pain directly
What are the properties of aspirin?
- analgesic
- antipyretic
- anti-inflammatory
What is the mechanism of aspirin?
- inhibits cylco-oxygenases (COX1 and COX2)
- this reduces the production of prostaglandins
- COX1 inhibition reduces platelet aggregation
Describe the analgesic properties of aspirin.
- peripheral and central action
- peripheral actions are more dominant
- analgesia results from inhibition of prostaglandins in inflamed tissues
Describe the antipyretic properties of aspirin.
- prevents temperature raising properties of IL-1
- prevents rise of prostaglandins in the brain
- reduces elevated temperature, not normal temperature
Describe the anti-inflammatory properties of aspirin.
- prostaglandins act as vasodilators and affect capillary permeability
- due to the reduction in prostaglandins, inflammation is reduced at site of injury
What are the adverse effects of aspirin?
- GIT problems
- hypersensitivity
- overdose
- aspirin mucosal burns
Describe the GIT problems caused by aspirin.
- due to the COX1 inhibition, platelet aggregation is reduced which predisposes the GI mucosa to damage
- prostaglandins usually protect the mucosal lining by increases blood flow through gastric mucosa and produce mucin cells which have a protective lining
Who should not be prescribed aspirin due to GIT problems?
- ulcers
- gastro-oesophageal reflux
Describe aspirin hypersensitivity.
- acute bronchospasm (asthma attacks)
- skin rashes
- urticaria (hives)
- angioedema
Who should not be prescribed aspirin due to hypersensitivity problems?
Care should be taken when prescribing aspirin to asthmatics
Describe aspirin overdose.
- hyperventilation
- tinnitus (deafness)
- vasodilator and swelling
- metabolic acidosis
- coma
Describe mucosal burns caused by aspirin.
- direct effect of salicylic acid
- chemical burn of the mucosa when left in the mouth “to absorb”
- aspirin has NO TOPICAL EFFECT
Who is at risk when prescribing aspirin?
- peptic ulceration
- epigastric pain
- bleeding abnormalities or those on anticoagulants
- pregnancy or breastfeeding
- steroids
- renal/hepatic impairment
- U16s
- asthmatics
- hypersensitivity to other NSAIDs or taking other NSAIDs
- elderly
- G6PD deficiency
Why are those with peptic ulcers at risk using aspirin?
Ulcers could perforate under the effects of aspirin
Why are those with epigastric pain at risk using aspirin?
- could be due to reflux
- undiagnosed ulcer
Why are those with bleeding abnormalities at risk using aspirin?
Aspirin has anticoagulant properties
Why are those taking anticoagulants at risk using aspirin?
- aspirin enhances the effects of warfarin and other anticoagulants
- displaces warfarin from binding site on plasma and therefore increases free warfarin
- increases bleeding tendency +++
Why are those who are pregnant at risk using aspirin?
- platelet function is inhibited
- +++ risk for haemorrhage
- increased risk of jaundice of baby
- prolong/delay labour
Why are those who are breastfeeding at risk using aspirin?
Increased risk of Reyes syndrome (brain condition)
Why are those taking steroids at risk using aspirin?
Patients on systemic steroids are at higher risk of developing peptic ulcers, if undiagnosed may perforate if prescribed aspirin