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Pharma > 3th > Flashcards

3th Flashcards

1
Q

What separates body compartments

A

Capillary walls and cell membranes

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2
Q

One compartmental model drugs (trapped in plasma compartment)

A

Heparin&dextran

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3
Q

Two compartmenal model (ECF) drugs

A

Aminoglycoside & mannitol

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4
Q

Multi-compartemntal model(ECF+ICF)

A

Ethanol & sulphonamide

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5
Q

Tissue reservior:iodine

A

Thyroid & salaivary glands

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6
Q

Tissue reservior: calcium and tetracycline

A

Bones & teeth

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7
Q

Tissue reservior: chloroquine

A

Liver

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8
Q

Tissue reservior: thiopental

A

Fat

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9
Q

Vd doesn’t describe real volume but what

A

Ratio of drug in the extraplasmic spaces relative to the plasma space

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10
Q

Small Vd drug

A

Frusemide

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11
Q

Large Vd drug

A

Digoxin

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12
Q

When is dialysis isn’t useful

A

For high Vd drugs (most of the drugs are in the tissue)

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13
Q

What kind of drugs bind mainly with albumin

A

Acidic and lipophilic

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14
Q

What is prefusion

A

Amount of drug which is delivered to a particular organ depending on blood flow

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15
Q

E.g on hypoalbuminemia

A

Starvation & malnutrition

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16
Q

Drug that becomes toxic if there’s hypoalbuminemia

A

Phenytoin

17
Q

Competition on plasma proteins: sulphonamide & aspirin displace what

A

Warfarin»bleeding

18
Q

Competition on plasma proteins: sulphonamide displace what

A

Bilirubin»kernicterus in premature neonates

19
Q

Passage of drugs to CNS lipid soluble

A

general anesthetics & CNS depressants

20
Q

Passage of drugs to CNS 3ry amines and 4ry NH4

A

3ry amines can pass
4ry NH4 CANNOT

21
Q

Passage of drugs to CNS some hydrophilic

A

Antibiotics: penicillin (inflamed BBB only)

22
Q

How drugs pass the placental barrier

A

Simple diffusion

23
Q

Passage of drugs to fetus: drugs given in 3th to 10th week of pregnancy

A

Teratogenicity (thalidomide»phocomelia)

24
Q

Passage of drugs to fetus: oral anticoagulants

A

Fatal hemorrhage

25
Q

Passage of drugs to fetus: oral hypoglycemics

A

Prolonged neonatal hypoglycemia

26
Q

Passage of drugs to fetus: aminoglycosides

A

8th cranial nerve damage

27
Q

Passage of drugs to fetus: during labor, morphine

A

Respiratory depression (asphyxia neonatorum)

28
Q

Passage of drugs to breast milk: sedatives,hypnotics,narcotics

A

CNS depression in baby

29
Q

Passage of drugs to breast milk: oral penicillins & purgatives

A

Diarrhea in baby

30
Q

Passage of drugs to breast milk: anticancer drugs

A

Decrease growth in baby

31
Q

Passage of drugs to breast milk: bromocriptine & sex hormones

A

Suppress lactation

Pharma (3 decks)

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