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Pharma > 2th > Flashcards

2th Flashcards

1
Q

Method of absorption for vitB12 and intrinsic factor

A

Endocytosis

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2
Q

VitB12 and intrinsic factor absorption site

A

Terminal ileum

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3
Q

Which is better at absorption solutions or suspensions

A

Solutions

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4
Q

Sustained-release preparations absorption rate?

A

Slow in absorption

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5
Q

Disintegration and dissolution rate for paracetamol and digoxin?

A

Rapid with paracetamol and slow with digoxin

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6
Q

Quarternary ammonium Compounds ionization form

A

Always ionized (poor absorption)

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7
Q

Tertiary amines (physostigmine)

A

Always unionized (better absorption)

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8
Q

Aspirn is acidic or basic?

A

Acidic

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9
Q

Amphetamine is acidic or basic?

A

Basic

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10
Q

Streptomycin ionization and absorption

A

High pka»ionized&raquo_space;poor absorption

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11
Q

Ion trapping aspirin cause what

A

Peptic ulceration

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12
Q

Route of administration absorption rate

A

IV>inhalation >IM>SC>Oral>skin

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13
Q

Absorbing surface vascularity absorption rate

A

Alveoli>skeletal muscles >subcutaneous

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14
Q

Surface area absorption rate

A

Intestines >stomach

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15
Q

What happens to absorption rate during diarrhea and malabsorption

A

Decrease in oral absorption

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16
Q

What happens to absorption rate during shock and heart failure

A

Decrease in absorption

17
Q

Vit.B12 specific factor

A

Intrinsic factor

18
Q

Vit.C increase the absorption of what

A

Iron

19
Q

What does the activated charcoal do to oral absorption

A

Decrease oral absorption of most drugs

20
Q

Impact of SC adrenaline to absorption rate

A

VC»>decrease absorption rate of local anesthetics»longer action duration

21
Q

Transdermal drugs E.g

A

Nitroglycerin,estrogen

22
Q

Irritant drugs that mustn’t be taken on empty stomach

A

Aspirin

23
Q

What decrease the oral absorption of tetracycline

A

Milk(calcium)

24
Q

Gastric acidity (pH) increase the absorption of what drugs

A

Acidic drugs: aspirin barbiturates

25
Q

Intestinal alkalinity increase the absorption of what drugs

A

Basic drugs: amphetamines and ephedrine

26
Q

What drug accelerate gastric emptying

A

Metocloperamide»increase paracetamol absorption

27
Q

What drug slow down gastric emptying

A

Atropine»decrease paracetamol absorption

28
Q

Drugs metabolized in their hepatic first pass effect

A

Nitroglycerin & propranolol

29
Q

Gut 1st pass effect :Gastric acidity

A

Benzyl penicillin

30
Q

Gut 1st pass effect : digestive enzymes

A

Insulin & pituitary hormones

31
Q

Gut 1st pass effect :mucosal enzyme

A

L-dopa & alpha-methyldopa

32
Q

Gut 1st pass effect :mucosal enzymes

A

L-dopa & alpha-methyldopa

Pharma (3 decks)

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