3D Structure of Antibodies

Question 1

IgG subclass that is the most efficient at binding complemet

Answer 1

IgG3

Question 2

The 5 monomeric chains of IgM are joined by:

Answer 2

J (joining) chain

Question 3

The primary response is characterized by a ____ lag phase, slow ____ in antibody, and a ____-lived response.

Answer 3

Long; increase; short

Question 4

While IgA2 is predominant in the mucosal surfaces, IgA1 is mainly found in:

Answer 4

Serum

Question 5

Process by which IgA and SC precursor are taken inside the cell and released to the opposite surface

Answer 5

Transcytosis

Question 6

Because of its unusually long hinge region, this immunoglobulin is more susceptible to proteolysis than other Igs.

Answer 6

IgD

Question 7

Most heat-labile of all the immunoglobulins

Answer 7

IgE

Question 8

Derived from a single parent antibody-producing cell that has reproduced many times, forming a clone

Answer 8

Monoclonal antibodies

Question 9

Fusion of 2 different cell types

Answer 9

Hybridoma

Question 10

Cancerous plasma cells

Answer 10

Myeloma cells

Question 11

After fusion of plasma cells with myeloma cells, all cells are placed in culture using a medium containing:

Answer 11

Hypoxanthine, aminopterin, thymidine (HAT)

Question 12

Builds DNA from degradation of old nucleic acids

Answer 12

Salvage pathway

Question 13

Myeloma cell line employed is deficient in:

Answer 13

Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) & thymidine kinase

Question 14

Makes DNA from new nucleotides

Answer 14

De novo pathway