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CYP 450 > 3A4/5 > Flashcards

3A4/5 Flashcards

1
Q

Apalutamide

A

Strong inducer, Substrate

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2
Q

Aprepitant

A

Inducer, Moderate inhibitor, Substrate

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3
Q

Armodafinil

A

Inducer

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4
Q

Bosentan

A

Moderate inducer, Substrate

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5
Q

Brigatinib

A

Inducer, Substrate

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6
Q

Carbamazepine

A

Strong inducer, Substrate

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7
Q

Corticosteroids

A

Inducer

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8
Q

Dabrafenib

A

Inducer, Substrate

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9
Q

Efavirenz

A

Moderate inducer

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10
Q

Encorafenib

A

Strong inducer

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11
Q

Enzalutamide

A

Strong inducer, Substrate

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12
Q

Etravirine

A

Moderate inducer, Substrate

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13
Q

Lorlatinib

A

Moderate inducer, Substrate

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14
Q

Lumacaftor

A

Moderate inducer

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15
Q

Modafinil

A

Moderate inducer

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16
Q

Nevirapine

A

Inducer, Substrate

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17
Q

Phenobarbital

A

Inducer

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18
Q

Phenytoin

A

Strong inducer

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19
Q

Rifabutin

A

Inducer, Substrate

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20
Q

Rifampicin

A

Strong inducer

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21
Q

Ritonivir

A

Inducer, Strong inhibitor, Substrate

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22
Q

Rufinamide

A

inducer

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23
Q

St John’s wort

A

strong inducer

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24
Q

Vemurafenib

A

inducer, Substrate

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25
Q

Amiodarone

A

Inhibitor, Substrate

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26
Q

Asciminib

A

Inhibitor, Substrate

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27
Q

Atazanavir

A

Moderate inhibitor, Substrate

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28
Q

Avacopan

A

Inhibitor, Substrate

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29
Q

Ceritinib

A

Strong inhibitor, Substrate

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30
Q

Ciclosporin

A

Moderate inhibitor, Substrate

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31
Q

Clarithromycin

A

Strong inhibitor, Substrate

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32
Q

Cobicistat

A

Strong inhibitor, Substrate

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33
Q

Crizotinib

A

Moderate inhibitor, Substrate

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34
Q

Darunavir

A

Inhibitor, Substrate

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35
Q

Diltiazem

A

Moderate inhibitor, Substrate

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36
Q

Encorafenib

A

Inhibitor, Substrate

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37
Q

Erythromycin

A

Moderate inhibitor, Substrate

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38
Q

Fluconazole

A

Moderate inhibitor

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39
Q

Fluvoxamine

A

Moderate inhibitor

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40
Q

Grapefruit juice

A

Moderate inhibitor

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41
Q

Idelalisib

A

Strong inhibitor, Substrate

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42
Q

Imatinib

A

Moderate inhibitor, Substrate

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43
Q

Isavucinazole

A

Moderate inhibitor, Substrate

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44
Q

Itraconazole

A

Strong inhibitor, Substrate

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45
Q

Ketoconazole

A

Strong inhibitor, Substrate

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46
Q

Larotrectinib

A

Inhibitor, Substrate

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47
Q

Lenacapavir

A

Moderate inhibitor, Substrate

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48
Q

Letermovir

A

Moderate inhibitor

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49
Q

Lopinavir

A

Inhibitor, Substrate

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50
Q

Maribavir

A

Inhibitor, Substrate

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51
Q

Miconazole

A

Inhibitor

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52
Q

Netupitant

A

Inhibitor, Substrate

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53
Q

Palbociclib

A

Inhibitor, Substrate

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54
Q

Posaconazole

A

Strong inhibitor

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55
Q

Ribociclib

A

Inhibitor, Substrate

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56
Q

Stiripentol

A

Inhibitor, Substrate

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57
Q

Ticagrelor

A

Inhibitor, Substrate

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58
Q

Verapamil

A

Moderate inhibitor, Substrate

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59
Q

Voriconazole

A

Strong inhibitor, Substrate

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60
Q

Abemaciclib

A

Substrate

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61
Q

Abiraterone

A

Substrate

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62
Q

Acalabrutinib

A

Substrate

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63
Q

Alfentanil

A

Substrate

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64
Q

Alprazolam

A

Substrate

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65
Q

Amitriptyline

A

Substrate

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66
Q

Apixaban

A

Substrate

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67
Q

Apremilast

A

Substrate

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68
Q

Aripiprazole

A

Substrate

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69
Q

Atorvastatin

A

Substrate

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70
Q

Avacopan

A

Substrate

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71
Q

Avanafil

A

Substrate

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72
Q

Avatrombopag

A

Substrate

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73
Q

Axitinib

A

Substrate

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74
Q

Betamethasone

A

Substrate

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75
Q

Bictegravir

A

Substrate

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76
Q

Bortezomib

A

Substrate

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77
Q

Brentuximab vedotin

A

Substrate

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78
Q

Brexpiprazole

A

Substrate

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79
Q

Buspirone

A

Substrate

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80
Q

Budesonide

A

Substrate

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81
Q

Busulfan

A

Substrate

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82
Q

Cabazitaxel

A

Substrate

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83
Q

Cabozantinib

A

Substrate

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84
Q

Cannabidol

A

Substrate

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84
Q

Cariprazine

A

Substrate

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85
Q

Cinacalcet

A

Substrate

86
Q

Cisapride

A

Substrate

87
Q

Clopidogrel

A

Substrate

88
Q

Cobimetinib

A

Substrate

89
Q

Cocaine

A

Substrate

90
Q

Codeine

A

Substrate

91
Q

Colchicine

A

Substrate

92
Q

Cyclophosphamide

A

Substrate

93
Q

Dapoxetine

A

Substrate

94
Q

Darifenacin

A

Substrate

95
Q

Darolutamide

A

Substrate

96
Q

Dasatinib

A

Substrate

97
Q

Dexamethasone

A

Substrate

98
Q

Diazepam

A

Substrate

99
Q

Disopyramide

A

Substrate

100
Q

Docetaxel

A

Substrate

101
Q

Domperidone

A

Substrate

102
Q

Donepezil

A

Substrate

103
Q

Eletriptan

A

Substrate

104
Q

Elexacaftor

A

Substrate

105
Q

Elvitegravir

A

Substrate

106
Q

Enfortumab vedotin

A

Substrate

107
Q

Entrectinib

A

Substrate

108
Q

Eplerenone

A

Substrate

109
Q

Ergometrine

A

Substrate

110
Q

Erlotinib

A

Substrate

111
Q

Esomeprazole

A

Substrate

112
Q

Ethinylestradiol

A

Substrate

113
Q

Etonogestrel

A

Substrate

114
Q

Etoposide

A

Substrate

115
Q

Etoricoxib

A

Substrate

116
Q

Everolimuse

A

Substrate

117
Q

Felodipine

A

Substrate

118
Q

Fentanyl

A

Substrate

119
Q

Finerenone

A

Substrate

120
Q

Fluticasone

A

Substrate

121
Q

Fluvastatin

A

Substrate

122
Q

Fostemsavir

A

Substrate

123
Q

Galantamine

A

Substrate

124
Q

Gefitinib

A

Substrate

125
Q

Filteritinib

A

Substrate

126
Q

Guanfacine

A

Substrate

127
Q

Haloperidol

A

Substrate

128
Q

Hydrocortisone

A

Substrate

129
Q

Ibrutinib

A

Substrate

130
Q

Ifosfamide

A

Substrate

131
Q

Imipramine

A

Substrate

132
Q

Irinotecan

A

Substrate

133
Q

Ivabradine

A

Substrate

134
Q

Ivacaftor

A

Substrate

135
Q

Lapatinib

A

Substrate

136
Q

Lemborexant

A

Substrate

137
Q

Lercanidipine

A

Substrate

138
Q

Levonorgestrel

A

Substrate

139
Q

Lidocaine

A

Substrate

140
Q

Lurasidone

A

Substrate

141
Q

Macitentan

A

Substrate

142
Q

Maraviroc

A

Substrate

143
Q

Mavacamten

A

Substrate

144
Q

Methylprednisolone

A

Substrate

145
Q

Midazolam

A

Substrate

146
Q

Midostaurin

A

Substrate

147
Q

Mifepristone

A

Substrate

148
Q

Mirabegron

A

Substrate

149
Q

Mirtazipine

A

Substrate

150
Q

Nifedipine

A

Substrate

151
Q

Nilotinib

A

Substrate

152
Q

Nimodipine

A

Substrate

153
Q

Nirmatrelvir

A

Substrate

154
Q

Norethisterone

A

Substrate

155
Q

Olaparib

A

Substrate

156
Q

Omeprazole

A

Substrate

157
Q

Ondansetron

A

Substrate

158
Q

Osimertinib

A

Substrate

159
Q

Oxycodone

A

Substrate

160
Q

Paclitaxel

A

Substrate

161
Q

Perampanel

A

Substrate

162
Q

Pazopanib

A

Substrate

163
Q

Pomalidomide

A

Substrate

164
Q

Ponatinib

A

Substrate

165
Q

Propranolol

A

Substrate

166
Q

Quetiapine

A

Substrate

167
Q

Quinine

A

Substrate

168
Q

Reboxetine

A

Substrate

169
Q

Regorafenib

A

Substrate

170
Q

Rilpivirine

A

Substrate

171
Q

Ripretinib

A

Substrate

172
Q

Risperidone

A

Substrate

173
Q

Rivaroxaban

A

Substrate

174
Q

Romidepsin

A

Substrate

175
Q

Ruxolitinib

A

Substrate

176
Q

Salmeterol

A

Substrate

177
Q

Sildenafil

A

Substrate

178
Q

Silodosin

A

Substrate

179
Q

Simvastatin

A

Substrate

180
Q

Siponimod

A

Substrate

181
Q

Sirolimus

A

Substrate

182
Q

Solifenacin

A

Substrate

183
Q

Sonidegib

A

Substrate

184
Q

Sorafenib

A

Substrate

185
Q

Sunitinib

A

Substrate

186
Q

Suvorexant

A

Substrate

187
Q

Tacrolimus

A

Substrate

188
Q

Tadalafil

A

Substrate

189
Q

Tamoxifen

A

Substrate

190
Q

Tezacaftor

A

Substrate

191
Q

Tiagabine

A

Substrate

192
Q

Tofacitinib

A

Substrate

193
Q

Tolterodine

A

Substrate

194
Q

Tolvaptan

A

Substrate

195
Q

Toremifene

A

Substrate

196
Q

Trabectedin

A

Substrate

197
Q

Tramadol

A

Substrate

198
Q

Triamcinolone

A

Substrate

199
Q

Ulipristal

A

Substrate

200
Q

Upadacitinib

A

Substrate

201
Q

Vandetanib

A

Substrate

202
Q

Velpatasvir

A

Substrate

203
Q

Venetoclax

A

Substrate

204
Q

Venlafaxine

A

Substrate

205
Q

Vinblastine

A

Substrate

206
Q

Vincristine

A

Substrate

207
Q

Vinorelbine

A

Substrate

208
Q

Voxilaprevir

A

Substrate

209
Q

Warfain (R-isomer)

A

Substrate

210
Q

Zanubrutinib

A

Substrate

211
Q

Ziprasidone

A

Substrate

212
Q

Zolpdem

A

Substrate

CYP 450 (8 decks)

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