3.8.1 Alternation Of The Sequence Of Bases In Dna Can Alter The Structure Of Protein

Question 1

Where does gene mutation arise

Answer 1

Meiosis and the random fertilisation of gametes during sexual reproduction
Mutations arise spontaneously during interphase, DNA replication

Question 2

Type of gene mutation

Answer 2

Substitution (point mutation)
Deletion / addition (frame shift)
Insertion (frame shift)
inversion (section rotation)
duplication (extra copy)
translocation (transfer) – shorter polypeptides

Question 3

Formation of non- functional enzyme

Answer 3

1. change in amino acid sequence / primary structure
2. Change in hydrogen / ionic bonds which alters tertiary structure / active site
3. Substrate cannot bind / no longer complementary / no enzyme-substrate complexes form;