3.4 Hemoglobin And Myoglobin

Question 0

T/F hemoglobin is found in RBC exclusively

Answer 0

true

Question 1

T/F Protoporphyrin III plus Ferritin iron makes up Heme

Answer 1

False. Ferrous iron

Question 2

Which of the following is matched correctly:
A. Embryonal: Liver
B. Fetal: Yolk Sac
C. HbA2: Conception up to first few months.
D. Fetal: First few months to after birth

Answer 2

D.
embryonal: yolk sac
Fetal: liver
HbA2: shortly after birth

Question 3

Configuration of Hemoglobin that has a lot of salt bridges

Answer 3

Taut

Question 4

Hemoglobin binds oxygen with increasing affinity

Answer 4

Positive cooperativity

Question 5

Consists of a single polypeptide chain composed of polar and non-polar AA.

Answer 5

Myoglobin

Question 6

Curve representation of the following:
Myoglobin
Hemoglobin

Answer 6

Myoglobin: hyperbolic
Hemoglobin: sigmoidal

Question 7

Critical Amount of oxygen in which myoglobin is released.

Answer 7

5mmHg

Question 8

T/F Allosteric effects are present in both myoglobin hemoglobin.

Answer 8

False. Hemoglobin only

Question 9

Which among the following doesn’t contribute to shift to the right of the dissociation curve of hemoglobin?
Increase in CO2, Decrease in pH, Increase in exercise and temperature, Decrease in 2,3BPG

Answer 9

Decrease in 2,3 BPG

Question 10

Give the only two reasons that can cause the shift of the curve to the left.

Answer 10

Increase in CO and increase in fetal hemoglobin

Question 11

Based on the Bohr effect which of the ff is true:
A. Increase in protons shifts the curve to the left.
B. Decrease in protons shifts the curve to the right.
C. Increase in pO2 shifts the curve to the right.
D. Decrease in pO2 shifts the curve to the right.

Answer 11

D.

Question 12

Which is false?
A. In infants, hemoglobin is more likely to have 2,3 BPG
B. In high altitudes, hemoglobin is more in a taut configuration.
C. In high altitudes, there are more production of erythropoietin.
D. In infants, hemoglobin is in a more relaxed configuration.

Answer 12

A.

Question 13

Treatment for chocolate cyanosis

Answer 13

Methylene blue

Question 14

Increase affinity of CN because oxidized form of iron doesn’t bind to hemoglobin

Answer 14

Methemoglobin

Question 15

Hemoglobin becomes cherry pink. CO increases its affinity in hemoglobin 200x.

Answer 15

Carboxyhemoglobin

Question 16

Target HbA1c

Answer 16

<7%

Question 17

Problem in the protein spectrin making RBC spheroidal leading it to destruction in spleen.

Answer 17

Hereditary spherocytosis

Question 18

Which among the following isn’t a manifestation of hereditary spherocytosis?
Anemia, neuropsychiatric symptoms, jaundice, splenomegaly

Answer 18

Neuropsychiatric symptoms

Question 19

Whichever of the following isn’t a manifestation of chocolate cyanosis?
Anxiety, headache, dyspnea, splenomegaly

Answer 19

Splenomegaly

Question 20

Disorder caused by production of structurally abnormal Hb molecule or insufficient amount of normal Hb.

Answer 20

Hemoglobinopathies.

Question 21

Point mutation of Bchain causing replacement of glutamate by valine

Answer 21

Sickle cell disease

Question 22

Point mutation of Bchain causing replacement of glutamate by lysine

Answer 22

Hemoglobin C

Question 23

This type of thalassemia show symptoms at birth.

Answer 23

Alpha thalassemia

Question 24

This thalassemia shows symptoms appear only after birth

Answer 24

Beta thalassemia