3.4 Hemoglobin And Myoglobin Flashcards
T/F hemoglobin is found in RBC exclusively
true
T/F Protoporphyrin III plus Ferritin iron makes up Heme
False. Ferrous iron
Which of the following is matched correctly:
A. Embryonal: Liver
B. Fetal: Yolk Sac
C. HbA2: Conception up to first few months.
D. Fetal: First few months to after birth
D.
embryonal: yolk sac
Fetal: liver
HbA2: shortly after birth
Configuration of Hemoglobin that has a lot of salt bridges
Taut
Hemoglobin binds oxygen with increasing affinity
Positive cooperativity
Consists of a single polypeptide chain composed of polar and non-polar AA.
Myoglobin
Curve representation of the following:
Myoglobin
Hemoglobin
Myoglobin: hyperbolic
Hemoglobin: sigmoidal
Critical Amount of oxygen in which myoglobin is released.
5mmHg
T/F Allosteric effects are present in both myoglobin hemoglobin.
False. Hemoglobin only
Which among the following doesn’t contribute to shift to the right of the dissociation curve of hemoglobin?
Increase in CO2, Decrease in pH, Increase in exercise and temperature, Decrease in 2,3BPG
Decrease in 2,3 BPG
Give the only two reasons that can cause the shift of the curve to the left.
Increase in CO and increase in fetal hemoglobin
Based on the Bohr effect which of the ff is true:
A. Increase in protons shifts the curve to the left.
B. Decrease in protons shifts the curve to the right.
C. Increase in pO2 shifts the curve to the right.
D. Decrease in pO2 shifts the curve to the right.
D.
Which is false?
A. In infants, hemoglobin is more likely to have 2,3 BPG
B. In high altitudes, hemoglobin is more in a taut configuration.
C. In high altitudes, there are more production of erythropoietin.
D. In infants, hemoglobin is in a more relaxed configuration.
A.
Treatment for chocolate cyanosis
Methylene blue
Increase affinity of CN because oxidized form of iron doesn’t bind to hemoglobin
Methemoglobin
Hemoglobin becomes cherry pink. CO increases its affinity in hemoglobin 200x.
Carboxyhemoglobin
Target HbA1c
<7%
Problem in the protein spectrin making RBC spheroidal leading it to destruction in spleen.
Hereditary spherocytosis
Which among the following isn’t a manifestation of hereditary spherocytosis?
Anemia, neuropsychiatric symptoms, jaundice, splenomegaly
Neuropsychiatric symptoms
Whichever of the following isn’t a manifestation of chocolate cyanosis?
Anxiety, headache, dyspnea, splenomegaly
Splenomegaly
Disorder caused by production of structurally abnormal Hb molecule or insufficient amount of normal Hb.
Hemoglobinopathies.
Point mutation of Bchain causing replacement of glutamate by valine
Sickle cell disease
Point mutation of Bchain causing replacement of glutamate by lysine
Hemoglobin C
This type of thalassemia show symptoms at birth.
Alpha thalassemia
This thalassemia shows symptoms appear only after birth
Beta thalassemia
