335 ALD

Question 1

Worlds third largest risk factor for disease burden

Answer 1

Alcohol

Question 2

Important comorbidity in the progression of alcoholic liver disease to cirrhosis and excessive drinkers

Answer 2

Chronic infection with HCV

Question 3

Hallmark of alcoholic hepatitis

Answer 3

Ballooning degeneration, spotty necrosis, PMN infiltration and fibrosis in the perivenular and perisinusoidal space of Disse

Question 4

Genetic association with alcoholic cirrhosis

Answer 4

PNPLA3

Question 5

What is equivalent to 12 grams of alcohol

Answer 5

1 bottle beer
4 Oz wine
1 oz 80% spirit

Question 6

Alcohol intake of how much in HCV infected patient leads to decrease efficacy of interferon based antiviral therapy

Answer 6

Alcohol intake of more than 50 grams/day

Question 7

Initial and most common Histologic response to hepatotoxicity stimuli including excessive alcohol ingestion

Answer 7

Fatty liver

Question 8

Major enzyme for alcohol metabolism

Answer 8

Alcohol dehydrogenase

Question 9

AST/ALT ratio is alcohol hepatitis

Answer 9

More than 1

Question 10

What is AST and ALT elevations in alcoholic hepatitis

Answer 10

AST and ALT are elevated 2 to 7 fold but rarely above 400 IU

Question 11

MELD score of what is associated with significant Mortality in alcoholic hepatitis

Answer 11

MELD score more than 21

Question 12

When is prednisone given to alcoholic hepatitis and how long

Answer 12

MELD score more than 20 OR discrimant function more than 32
Prednisone 40 mg/day x 4 weeks
Prenisolone 32 mg/day x 4 weeks