332 Hepatitis Flashcards
What is the first virology marker to be detected after a person is infected with HBV, usually in 1-12 weeks?
HBsAg
All human hepatitis virus are RNA viruses except for
hepatitis B which is a DNA virus but replicates like a retrovirus
in HAV, this is the early antibody response and this persists for how long
early antibody response is predominantly of the IgM class and persists for 3 months
during covalescence, what is the predominant antibody
IgG class
the envelope protein expressed on the outer surface of the virion and on the smaller spherical and tubular structures
Hepatitis B surface antigen (HbsAg)
antigen expressed on the surface of the nucleocapsid core
Hepatitis B core antigen (HBCAg)
a soluble nonparticulate nucleocapsid protein distinct from HBCAG but product of the same gene
HbeAg
after a person is infected with HBV, what is the first virologic marker detectable in serum 8-12 weeks
HbsAg
circulating HbsAg precedes elevation of serum aminotransferase and symptoms by how many weeks
2-6 weeks
what antibody becomes detectable after HbsAg disappears and persists for how long
anti Hbs becomes detectable and remains detectable indefinitely
during the gap or window period, antibody may represent the only serologic evidence of current or recent HBV infection
anti Hbc
gap between the disappearance of Hbsag and antiHBs
window period
True or false. An isolated anti Hbc does not necessarily indicate active virus replication
true. It can represent HBV infection in the remote past
how to distinguish recent or remote HBV infection
Ig class of anti Hbc
Ig of anti Hbc predominates in the first 6 months? Beyond the 6 months
anti Hbc IgM predominates in the first 6 months while anti Hbc IgG is the predominant class beyond 6 months
