3.3.4 Mass Transport Flashcards
What is meant by mass transport?
The bulk movement of materials from exchange surfaces to the cells throughout the organism
What is Fick’s law?
concentration gradient x surface area
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diffusion pathway
what does whether an organism need a mass transport system rely on?
how active the organism is (waste produced, material required), how far away is the external environment, calculated using Fick’s law
when would a mass transport system be faster than diffusion?
when the majority of cells are too far away from exchange surface
What do efficient systems have to maximise diffusion?
A suitable transport medium (usually liquid but can be gas, materials such as oxygen and waste dissolve), a closed system of tubular vessels (contains/holds medium, branching to all parts, medium is close to cells), mechanisms for movement of tissue fluid (generates pressure, enables medium to move)
What is the medium in the circulatory system?
Blood containing haemoglobin to carry oxygen
What is the closed system of tubular vessels in the circulatory system?
Veins, arteries and capillaries
What is the mechanism for movement in the circulatory system?
The heart
What are the four chambers of the heart?
Left ventricle, right ventricle, right atrium, left atrium
What are the vessels coming to and from the heart?
Pulmonary artery, pulmonary vein, aorta, vena cava
What is the function of valves?
to prevent the back flow of blood
Where is the SAN node located?
The top of the right atrium
What type of muscle is the heart?
A cardiac muscle
What system is the heart part of?
The circulatory system
What is meant by myogenic?
The heart naturally contracts and relaxes
What is meant by a double circulatory system?
Blood passes through the heart twice, through two different circuits, circuit one links the heart to the rest of the body, circuit two links the heart to the lungs
Describe the journey of a red blood cell, naming the main blood vessels and chambers of the heart.
Deoxygenated red blood cells enter the right atrium via the vena cava, it then moves through an atrioventricular valve into the right ventricle and pushed through a semi lunar valve into the pulmonary artery and towards the lungs. At the lungs oxygen diffuses into the blood and carbon dioxide diffuses out. Oxygenated blood then re-enters the heart through the pulmonary veins into the left atrium, it then moves through the left atrioventricular valve into the left atrium and through the left semi lunar valve into the aorta where it is transported around the body for oxygen diffuses into the working muscles. The cycle then starts again
how does the wall thickness in the heart maximise mass transport?
The left ventricle is much thicker as it is more muscular for a more forceful contraction as it requires more pressure to pump oxygenated blood around the body to the respiring cells and then back to the heart. Right ventricle not as thick as blood only travels to the lungs so requires lower pressure
How do the valves in the heart maximise mass transport?
They open and close between the atrium and ventricle and ventricle and vessels, they prevent the back flow of blood, to move the blood in one direction and only open when the chamber is filled
Which valves are between the atrium and ventricle?
Right atrioventricular (bicuspid valve) and left atrioventricular (tricuspid valve)
Which valves are between the ventricles and vessels?
Semi-lunar valves
How to the valves close?
Pressure is higher below the valve where concave, ventricle fills with blood, pushes the flexible, fibrous tissue together, tissue form a tight fit/no gap, causes the ‘lub dub’ sound, prevents blood from moving backwards
How do the valves open?
Pressure is higher above the valve, atrium fills with blood, ventricle empties, pushes the flexible, fibrous tissue apart, tissue form a gap, so blood can flow through
What is valve disease?
Leaky valve, can’t prevent the back flow , forms clots, doesn’t get enough oxygen as less pressure, lack energy
What are the treatments for valve disease?
Mechanical valves, animal valves (pigs or cows)
What are the advantages of using animal valves to treat valve disease?
Cows are in large supply, fairly well tested, fewer long term issue
What are the disadvantages of using animal valves to treat valve disease?
Unethical to use cows, not suitable for all, some feelings, can need replaced
How many times does the heart contact each minute at rest?
Around 70 times
What is meant by diastole?
Relaxation of the heart
What is meant by systole?
Contraction of the heart
What is haemoglobin?
A quaternary structure protein, a respiratory pigment, transports oxygen in the blood
What is the quaternary structure of haemoglobin?
2 beta and alpha polypeptides and each subunit has a haem group that contains a Ferrous ion (Fe2+) has four haem groups, each carries one O2 molecule, when combined with oxygen makes oxyhaemoglobin
What must haemoglobin do to be efficient?
Readily associate with oxygen at the exchange surface, readily dissociate with oxygen at the tissue
What is meant by affinity?
The attractive force binding atoms in molecules; chemical attraction
What is meant if haemoglobin has a high affinity?
Readily associates to oxygen
What is meant if haemoglobin has a low affinity?
Take up O2 less readily BUT release more readily (easily dissociates)
What is the oxygen concentration at the exchange surface i.e the lungs?
High
What is the carbon dioxide concentration at the exchange surface i.e the lungs?
Low
What is the affinity for oxygen at the exchange surface i.e the lungs?
High
What is the result at the exchange surface i.e the lungs?
Oxygen is more readily associated
What is the oxygen concentration at the respiring tissue i.e muscle?
Low
What is the carbon dioxide concentration at the respiring tissue i.e muscle?
High
What is the affinity for oxygen at the respiring tissue i.e muscle?
Low
What is the result at the respiring tissue i.e muscle?
Oxygen is more readily dissociated
What does affinity differ due to?
Metabolic rate and oxygen availability
What is meant by the environment affecting the affinity for oxygen?
How much oxygen is available, partial pressure of oxygen (the amount of a gas present in a mixture of gases, measured in kPa)
What is meant by metabolic rate affecting affinity for oxygen?
How much oxygen is required by the organism, sum of chemical reactions in the body
What happens with haemoglobin if the environment has a low partial pressure of oxygen?
Need haemoglobin to hold onto oxygen, high affinity for oxygen, holds onto oxygen more tightly but means that oxygen will not be used as readily, organisms have a low metabolic rate
What happens with haemoglobin if the environment has a high partial pressure of oxygen?
Oxygen is readily available, do not need to hold onto oxygen (weak attraction), low affinity for oxygen so oxygen dissociates easily
What is meant by partial pressure?
The amount of a gas present in a mixture of gases, how much pressure is caused by the molecule, measured in kPa
Why is the first oxygen difficult to attach to haemoglobin?
Because of bonds and tight structure
Why are the second and third oxygens easier to bind to haemoglobin?
Changed shape means can easily associate, disrupts bonds in the structure
Why is the last oxygen difficult to attach to haemoglobin?
Fewer binding sites so difficult to fully saturate
Wha is an oxygen dissociation curve?
Shows the relationship between the saturation of haemoglobin and the partial pressure of oxygen
What happens in stage one of an oxygen dissociation curve?
The saturation increases slowly because at low partial pressure it is difficult for the first oxygen to attach as there is less collisions as there is less oxygen, also because there is more bonds and a tight structure of haemoglobin
What happens in stage two of an oxygen dissociation curve?
The saturation increases rapidly as the first oxygen has disrupted the bonds, the changed shape means that oxygen can easily associate because of positive cooperativity
What happens in stage 3 of an oxygen dissociation curve?
There is only one binding site and a high partial pressure meaning there is more competition so it is difficult to fully saturate
What causes an oxygens dissociation curve to shift to the right?
Lower oxygen affinity, lower saturation or lower partial pressure, needs higher partial pressure for saturation, takes longer to become saturated
What causes an oxygen dissociation curve to shift to the left?
Higher affinity to oxygen so reaches saturation quicker, higher saturation at lower partial pressure, holds onto oxygen tightly
What happens when haemoglobin is exposed to different partial pressures of oxygen?
It does not absorb the oxygen evenly
What happens at very low concentrations of oxygen?
The four polypeptides of the haemoglobin molecule are closely united so it is difficult to absorb the first oxygen molecule, however this oxygen molecule causes the polypeptides to load the remaining oxygen molecules very easily
What does the shape of an oxygen dissociation curve reveal?
A very small decrease in the partial pressure leads to a lot of oxygen becoming dissociated from haemoglobin, the graph tails off at very high oxygen concentrations because haemoglobin is almost saturated with oxygen
what effect does carbon dioxide have on haemoglobin?
haemoglobin has a reduced affinity for oxygen in the presence of CO2- the greater the concentration of CO2, the more readily oxygen is released
what is the Bohr effect?
explains why the behaviour of haemoglobin changes in different regions of the body