3.2.3 Transport across cell membranes Flashcards
what are plasma membranes?
all membranes in and around all cells, they have the same basic structure
what is the cell surface membrane?
the plasma membrane that surrounds cells and forms the boundary between the cell cytoplasm and the environment
what is the function of the cell surface membrane?
allows different conditions to be established inside and outside a cell, it controls the movement of substances in and out of the cell
what is the structure of a phospholipid?
a hydrophilic (polar) phosphate head, a hydrophobic (non polar) fatty acid tails
what are the functions of phospholipids in the membrane?
allow lipid soluble substances to enter and leave the cell, prevent water soluble substances entering and leaving the cell
how do both parts of the phospholipid bilayer behave?
the hydrophilic heads of both phospholipid layers point to the outside of the cell-surface membrane attracted to water on both sides, the hydrophobic tails of both phospholipid tails of both phospholipid layers point into the centre of the cell membrane, repelled by water on both sides
what are the components of the cell surface membrane?
phospholipids, proteins (intrinsic and extrinsic), cholesterol, glycolipids, glycoproteins.
what is the function of extrinsic proteins?
occur in the surface of the bilayer and never extend completely across it, they act either to give mechanical support to the membrane or, in conjunction with glycolipids, as cell receptors for molecules such as hormones
what is the function of intrinsic proteins?
proteins that completely span across the phospholipid bilayer from one side to the other, some are protein channels which form water filled tubes to allow water soluble ions to diffuse across the membrane and others are carrier proteins that bind to ions or molecules like glucose and amino acids, then change shape in order to move across the membrane.
what are the functions of proteins in the membrane (intrinsic and extrinsic)?
provide structural support, act as channels transporting water soluble substances across the membrane, allow active transport across the membrane through carrier proteins, form cell surface receptors for identifying cells, help cells adhere together, act as receptors e.g. for hormones
what is cholesterol?
cholesterol molecules occur in the phospholipid bilayer of cell surface membranes, they are very hydrophobic and therefore play an important role in preventing the loss of water and dissolved ions from the cell, they also pull together the fatty acid tails of the phospholipids, limiting their movement and that of other molecules but without making the membrane as a whole too rigid
what are the functions of cholesterol in the membrane?
reduce lateral movement of molecules including phospholipids, make the membrane less fluid at high temperatures, prevent leakage of water and dissolved ions from the cell
what are glycolipids?
made up of a carbohydrate covalently bonded with a lipid, the carbohydrate portion extends from the phospholipid bilayer into the watery environment outside the cell where it acts as a cell surface receptor for specific chemicals, for example the human ABO blood system operates as a result of glycolipids on the cell surface membrane
what are the functions of glycolipids?
act as recognition sites, help maintain the stability of the membrane, help cells attach to one another and so form tissues
what are glycoproteins?
carbohydrate chains are attached to many extrinsic proteins on th eouter surface of the cell membrane, these glycoproteins also act as cell surface receptors , more specifically for hormones and neurotransmitters
what are the functions of glycoproteins?
act as recognition sites, help cells attach to one another and so form tissues, allows cells to recognise one another, e.g. lymphocytes can recognise an organism’s own cell
why can some molecules not pass through the membrane via simple diffusion?
not soluble in lipids and therefore cannot pass through the phospholipid layer, too large to pass through the channels in the membrane, electrically charged (polar) and therefore have difficulty passing through the non polar hydrophobic tails in the phospholipid bilayer, water soluble molecules cannot pass the hydrophobic tails
why is the model of the cell membrane known as a fluid mosaic?
fluid because the individual phospholipid molecules can move relative to each other, this gives the membrane a flexible structure that is constantly changing shape, mosaic because the proteins that are embedded in the phospholipid bilayer vary in shape, size and pattern in the same way as the stones in a mosaic do
what is diffusion an example of?
passive transport
what is meant by diffusion as a passive process?
passive means that the energy comes from the natural, inbuilt motion of particles, rather than from some external source such as ATP, all particles are constantly in motion due to the kinetic energy they possess, this motion is random with no set pattern to the way particles move around
what is diffusion defined as?
the net movement of molecules or ions from a region where they are more highly concentrated to one where their concentration is lower, down a concentration gradient until equilibrium is met
what factors affect the rate of diffusion?
temperature (more kinetic energy), surface area (how much space to diffuse across e.g. villi and micro villi in small intestine), concentration gradient (the difference between the two conditions)
what is meant by semi permeable?
allows some substances through but not others
which substances need to move in and out of our cells?
oxygen (for respiration), carbon dioxide (too much is toxic), glucose (need for respiration), ions (opposing charges), lipids (solubility), protein/amino acids (growth and repair), glycerol and fatty acids (membranes, make new fats), urea (toxic)
what is fick’s law?
states a relationship between the rate of diffusion at a constant temperature and three variables: concentration gradient, length of diffusion pathway, surface area over which diffusion is occurring
rate of diffusion is directly proportional to surface area x concentration gradient/length of diffusion pathway
why does an increase of concentration gradient increase the rate?
there are more particles to move, further away from equilibrium, more space to move into