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NAPLEX > 32. Anticoagulation > Flashcards

32. Anticoagulation Flashcards

1
Q

Types of Anticoagulants

A
  1. Heparin
    - Unfractionated Heparin (UFH)
    - Low Molecular Weight Heparin (LMWH)
  2. Factor Xa Inhibitor
  3. Direct Thrombin Inhibitors
  4. Vitamin-K dependent Factor - warfarin
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2
Q

Low Molecular Weight Heparin (LMWH)

A
  1. Enoxaparin (Lovenox)

2. Dalteparin (Fragmin)

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3
Q

Enoxaparin

A

Lovenox

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4
Q

Dalteparin

A

Fragmin

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5
Q

Oral Direct Factor Xa Inhibitors

A

Apixaban (Elliquis)
Rivaroxaban (Xarelto)
Edoxaban (Savaysa)
Betrixaban (Bevyxxa)

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6
Q

Apixaban

A

Elliquis

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7
Q

Rivaroxaban

A

Xarelto

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8
Q

Injectable Indirect Factor Xa Inhibitors

A

Fondaparinux (Arixtra)

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9
Q

Fondaparinux

A

Arixtra

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10
Q

Oral Direct Thrombin Inhibitors

A

Dabigatran (Pradaxa)

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11
Q

Dabigatran

A

Pradaxa

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12
Q

Injectable Direct Thrombin Inhibitors

IV, SC

A

Argatroban
Bivalirudin (Angiomax)
Desirudin (Iprivask)

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13
Q

Bivalirudin

A

Angiomax

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14
Q

Desirudin

A

Iprivask

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15
Q

Warfarin

A

Coumadin

Jantoven

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16
Q

Heparin Antidote

A

Protamine

17
Q

Antidote for Apixaban and Rivaroxaban

A

Andexanet (Andexxa)

18
Q

Antidote for Dabigatran

A

Idarucizumab (Praxbind)

19
Q

Antidote for Injectable Direct Thrombin Inhibitors

A

NO antidote

20
Q

Andexanet

A

Andexxa

21
Q

Idarucizumab

A

Praxbind

22
Q

Antidote for Warfarin

A

Vitamin K

23
Q

Monitoring parameter for Anticogulation

A
  1. aPTT/PTT - UFH
  2. Usually NOT but anti-Xa factor level - LMWH
  3. PT/INR - warfarin
24
Q

UFH dosing, VTE prophylaxis

A

5,000 units SC Q8-12 H

25
Q

UFH dosing, VTE treatment

A

Bolus: 80 units/kg. MAX: 5,000 units

Continuous Infusion: 18 units/kg/hr. MAX: 1,000 units/hr

26
Q

UFH dosing, ACS/STEMI treatment

A

Bolus: 60 units/kg. MAX: 4,000 units

Continuous infusion: 12 units/kg/hr. MAX: 1,000 units/hr

27
Q

LMWH dosing, VTE treatment

A

30 mg SC Q12H OR 40 mg SC daily

If CrCl <30 ml/min: 30mg SC QD

28
Q

LMWH dosing, VTE/UA/NSTEMI treatment

A

1 mg/kg/ SC Q12H or 1.5 mg/kg/SC QD (inpatient

If CrCl < 30 ml/min: 1mg/kg SC QD

29
Q

LMWH dosing, STEMI treatment, < 75 yo

A

Bolus: 30 mg IV + 1mg/kg SC
Followed by: 1mg/kg SC Q12H (MAX: 100 mg for the first 2 SC doses only)

If CrCl< 30 ml/min then
Bolus: 30 mg IV + 1mg/kg SC
Followed by 1 mg/kg/SC QD

30
Q

LMWH dosing, STEMI treatment, 75 yo and above

A

NO bolus
0.75 mg/kg SC Q12H (MAX: 75 mg for the first 2 SC doses ONLY)

If CrCl < 30 ml/min: 1mg/kg SC QD

NAPLEX (8 decks)

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