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OSCE drugs > 3153 Neuro > Flashcards

3153 Neuro Flashcards

1
Q

Carbamazepine PGx tests

A

Compulsory to test for HLA-B*1502
for SJS/TEN

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2
Q

Carbamazepine DDI (3)

A

Contraceptives, macrolides, grapefruit (CYP3A4)

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3
Q

Anti-epileptic ADRs (4)

A
  1. Suicidal ideation
  2. GI (N/V/D/C)
  3. Dizziness, headaches
  4. Hypersensitivity (SJS/TEN)
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4
Q

Lithium Toxicity

A

STAND
1. Sodium depletion
2. Thiazide
3. ACEi
4. NSAIDs
5. Dehydration

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5
Q

Lithium ADR (4)

A
  1. Tremors
  2. Hypothyroidism
  3. Cognitive impairment
  4. Weight gain
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6
Q

Antipsychotic ADRs (4)

A
  1. EPSE (dystonia, pseudo-PD, akathisia, tardive diskinesia)
  2. Hyper-prolactinaemia
  3. Metabolic (weight gain, DM)
  4. Orthostatic Hypotension (fall)
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7
Q

Clozapine ADR + CI

A

Agranulocytosis, CI with Carbamazepine

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8
Q

Triptans ADR (3)

A
  1. Serotonin Syndrome
  2. Pressure on chest, Nausea
  3. CVS conditions
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9
Q

Mirtazapine ADRs (2)

A
  1. Somnolence / Sedation
  2. Weight gain
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10
Q

TCA serious ADRs (3)

A
  1. CVS problems (avoid)
  2. Serotonin syndrome
  3. Seizure
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11
Q

SSRI / SNRI ADRs (4)

A
  1. Nausea
  2. Sexual dysfunction
  3. Anticholinergic / sedation
  4. Suicide risk
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12
Q

Madopar CI (2)

A
  1. Pregnancy
  2. Acute close angle glaucoma
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13
Q

Madopar ADRs (4)

A
  1. Orange sweat, urine
  2. N/V , drowsiness
    3.Hypotension
  3. dyskinesias (motor complication)
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14
Q

Dopamine agonists ADR (compared to Madopar)

A
  1. More hallucination
  2. less motor complications
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15
Q

MAO-Bi

A

cannot use with SSRI/SNRI, TCA, dextromethorphan, phenylephrine, dopamine, tyramine

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16
Q

COMTi

A

must use with concurrent levodopa

17
Q

NMDAs (Amantadine, memantine) ADR

A
  1. Livedo reticularis (net-like, purple discolouration of skin)
  2. Hallucination, confusion, dizziness
18
Q

Acetylcholinesterase inhibitor ADR (2)

A
  1. Bradycardia
  2. N/V/D
19
Q

BZD CI

A

concurrent use with opioids, alcohol

20
Q

MAOi

A

wash out period of 14 days with other serotonergic agents

OSCE drugs (9 decks)

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