3.1.5 Beta and Alpha Blockers

Question 1

What do B blockers do?

Answer 1

Block NorAd, reducing inotropy and chronotropy also decreases renin secretion

Question 2

What are some adverse effects of BBs?

Answer 2

BLOCKER

Bronchospasm
Lethargy
Heart block
Erectile dysfunction
Raynauds
Mask tachycardia- sign of insulin induced hypoglycaemia

Question 3

What are some examples of beta blockers?

Answer 3

Labetalol
Bisoprolol
Metoprolol

-lol suffix

Question 4

Which beta blockers are selective for which receptor?

Answer 4

A-N start =B1
O-Z start = B2

Not -olol blocks alpa and beta

Question 5

When can you not give BBs?

Answer 5

Asthma
COPD
Liver failure
Haemodynamic instability

Question 6

What are some important drug interactions for BBs?

Answer 6

Alkylamines e.g. Verapamil
Benzothiazepines e.g. Diltiazem

Can lead to asystole

Question 7

How do alpha blockers work?

Answer 7

Selective antagonist for a1 adrenoceptors

Relatively safe in renal disease

Question 8

What do Alpha Blockers do?

Answer 8

Reduce peripheral vascular resistance
Can be used in urinary tract, including bladder neck and prostate, especially in BPH (tamulosin)

Question 9

What are some adverse effects of alpha blockers?

Answer 9

Postural hypotension
Dizziness
Syncope
Headache
Fatigue

Question 10

What can alpha blockers cause?

Answer 10

Postural hypotension

Question 11

What are some important drug interactions of alpha blockers?

Answer 11

Dihydropyridines, can cause oedema

Question 12

What is an example of an alpha blocker?

Answer 12

Doxazosin

-osin suffix