3.1.4: Identifies abnormal colour vision & appreciates significance Flashcards
What % of males have CVD? What is the breakdown of the %?
8% of males have CVD
5% are deuteranomolous trichromat
1% are deuteranope
1% are protanomalous trichromat
1% protanope
Why is it important to test colour vision?
Careers: pilots, armed forces, police, electrical engineers
Safety: traffic lights, electrical wiring
Pathologies
What is colour theory?
- responses from 3 types of photoreceptor are transformed by complex neural network in retina so at level of ganglion cells colour info is coded into:
- 2 opponent colour channels: red v green, blue v yellow
- 1 opponent luminance channel: black v white (brightness/luminance)
- Human eye can see 380nm - 780nm using (tricolour) three photoreceptors (S, M, L cone) of overlapping spectral sensitivity (Receptor level).
- Cones S, M, L function at high level illuminance, rods fnction at low level illumminance
Describe vision being trichromatic?
Each photopigment is maximally (but not exclusively) sensitive to a different region of visible EM spectrum
- Red (long wavelength 620nm - 720nm)
- Green (medium wavelength 500nm - 575nm)
- Blue (short wavelength 450nm - 490nm)
* Blue cones are absent in central fovea
* Red/green cone ratio vary greatly from person to person
Describe congenital CVD?
- Higher incidence in men than women as X-linked autosomal recessive trait (1 in 12 males, 1 in 250 females)
- Protan: confuse reds and greens, both appear desaturated yellow
- Deutan: confuse reds and greens, both appear desaturated yellow
- Tritan: confuse blues, yellows & greens, appear pink/turquoise
Describe monochromats?
- One functioning cone
- Cone monochromat: single functioning cone
- Rod monochromat: no functioning cones, leads to:
o decreased VA
o photophobia
o nystagmus
o Only percieve brightness variations
Describe dichromacy (absent cone)?
- 2 active cones, 1 non-active
- Protanope 1% (L cone missing, red)
- Deuteranope 1% (M cone missing, green)
- Tritanope 0.001% (S cone missing, blue)
Describe anomalous trichromacy (defective cone)?
- All 3 cones are active but 1 or more has abnormal sensitivity
- Protanomaly 1% (abnormal red cone sensitivity, red defect)
- Protanomalous: red cone sensitivity is shifted towards green cone (shorter wavelengths)
- Deuteranomaly 4.9% (abnormal green cone sensitivity, green defect)
- Deuteranomalous: green cone sensitivity shifted towards red cones (longer wavelengths)
- Tritanomaly (abnormal blue cone sensitivity, blue defect)
- Tritanomalous: blue cone sensitivity shifted towards green cone (longer wavelengths)
What are the colour confusion that protans, deutans or tritans may mix up?
Protan:
- yellow-red/yellow/green-yellow
- violet/blue-green
-purple/grey/green
- brown/green
- red/black
Deutan:
- yellow-red/yellow/green-yellow
- violet/blue-green
- purple/grey/green
- brown/green
- green/black
Tritan:
- blue-green/green
- purple/red
- yellow/white
- violet/grey/yellow-green
- dark blue/black
Describe acquired CVD and the 3 types?
- Secondary to pathology (ocular and systemic), drug linked, defects fluctuate in severity, associated with decreased VA & VF
- Usually monocular & asymmetrical
- Usually blue-yellow
- Type 1: similar to protan - red/green - found in macular dystrophy/hydroxychloroquine retinal toxicity (rheumatoid arthritis)
- Type 2: similar to deutan - red/green - found in retrobulbar optic neuritis (common with ONH defect)
- Type 3: similar to tritan - blue found in many central & peripheral retinal lesions & lesions of visual pathway - POAG, AMD, DR
When should you test colour vision?
- children at 1st eye test - especially boys
- family history of CVD especially mother
- sxs suggestive of impaired colour discrimination
- occupational purposes
- aid in diagnosis or investigation of ocular or systemic disease
- suspected as side effect of medication or injury
What should you consider when using a colour vision test?
Illumination
* results are only valid if the test is administered under the recommended
illumination conditions
o appearance of spectral colours changes with spectral content of the
illuminant (daylight).
Refractive correction
* perform at end of test with appropriate refraction in place
Viewing distance
* Needs to be exact to ensure observations are being made with the central rod
free retinal area
Viewing time
* Short (few seconds) to limit the effects of colour adaptation
Monocularly
* To prevent influence from the fellow (potentially unaffected) eye
Describe the Ishihara colour vison test?
- 38 or 24 plate version (14 screening plates, 2 classification plates, pathway plates non-verbal or numeric)
- Does not grade severity - no. of plates missed does not grade severity
- Pass or fail
- Classification indicate type of defect
- 3 fails pass on 38, 2 fails pass on 24, 6 fails or more then FAIL
- Viewing time is 4 seconds per plate
- Viewing distance 75cm
- Illumination needs to be at least 250 lux - daylight best - Tungston not allowed due to bias, fluorescent is allowed
- Ishihara can ONLY detect protan & deutan –> a tritan will pass it
Describe the plate types in Ishihara test?
- First plate is a test plate always - only a brightenss difference
- Transformation plates - normal sees one number, CVD sees another
- Vanishing plates - camouflage principle, normal sees number, CVD does not
- Hidden digit plates - only seen by CVD px
- Classification plates - only used if screening plates failed to identify defect
- Non-numeric - should be traced <10secs but do not touch the page
24 plate:
Plate 1 demo, P2-9: screening type transformation, P10-13: vanishing, P14-15: hidden dig, P16-17: classification plates, P18-23: tracing (if px can’t read no.s), P24 (trace everyone can do)
38 plate:
P1: demo, P2-9: transformation, P10-17: vanishing, P18-21: hidden digits, P22-25: classification, P26-38: tracing (if px can’t read no.s)
What are the +ves and -ves of Ishihara test?
+ves:
- quick and efficient
- simple to use
- high sensitivity and specificity when performed correctly
-ves:
- no tritan detecting ability
- does not diagnoses severity
- screening plates are very sensitive - risk of false +ves