3.1 questions Flashcards
Normal Range for Fasting Glucose
3-5.4 mmol/L
Normal Range for random glucose
3-7.7 mmol/L
Normal HbA1c level
4.7-6.1%
Normal pulse in Adults
60-100 BPM
Normal Resp Rate in adults
14
Normal BP in adults
<130/85
Fever
Oral > 37.2
Rectal >37.7
DM diagonostic criteria
Random 1 reading if symptomatic
2 reading if asymptomatic >11.1 mmol/L
Fasting >7.0 mmol/L
or 2 values of oral GGT
Hypokalemia
< 3.5 mmol/L
Serum bilirubin in Jaundice
> 19 umol/L
Hyperkalemia
>5 mmol/L
Excessuve alcohol drinking
Males > 4 /day
Females > 2 /day
Anaemia - Hb
Males < 130 g/L
Females < 115 g/L
Classificaton of BMI
Normal = 20-25
Overweight > 25
Obesity > 30
Important General Questions in history
Fatigue, tiredness or malaise
Fever, sweating, shakes
Weight change esp loss
Pain or discomfort
Any unusual lumps or numps
Any unusual bleeding
Skin problem - rash or itching
Most common cause (bacterial) of traveller’s diarrhoea
Escherichia coli
Campylobacter species
Travel infections transmitted by mosquitoes
Malaria
Yellow fever
Rift valley fever
Japanese B encephalitis
Chikungunya
Dengue fever
Onset of travellers diarrhoea
6-12 hours afters infected food or water
most common cause = water or ice, unclean utensil and so on
Traveller’s Diarrhoea
6-12 hours after ingestion
Last 2-3 days
Symptoms = abdominal cramps, frequent diarrhoea with loose watery stoools and possible vomiting
Very severe with passing of blood or mucus = shigella sp . camplobacter sp and amoebiasis
otherwise think E.Coli, Campulobacter sp, Shingella sp and Slamonella
Treatment = Rehydration
with antimotility Ioperamide (Imodium) or antibiotics (if moderate-severe) like Norfloxaxine or azithromycin
Main 2 cause of presistent diarrhoea
Amoebiasis or giardiasis
Species that cause Malaria
Plamodium Vivax and Plasmodium Ovale
Plasmodium Falciparum = Malignant
Plasmodium Malariae
Plasmodium Kowlesi
Presentation of Malaria
Always think in any returned traveller
Fever + Chills + headache
- High fevers
Malaria Prophylaxsis drugs
Chloroquinine - approved for pregnancy, aggravates psoriasis, causes retinopathy
Doxycycline - Photosensitivity reactions
Mefloquine - cause dizziness, fuzzy head, blurred vision and neuropsychiatric
Atovaquone + Proquanil - avoid in pregnancu, kidney impairement. Causes Gi upsetm headache, dizziness, myalgia
Compulsary two vaccination for visiting ‘high risk’ areas
Yellow Fever
Meningococcus
Yellow Fever
Symptoms, Diagnosis, treamtent
Viral infection spread by Aedes Mosquitoes
- Symptoms - Fever + Bradycardia + Jaundice + bleeding
- Flu like-symptoms with relative bradycardia (THINK YELLOW FEVER IN BRADYCARDIA) =
- Bradycardia = Faget’s sign
- Albuminuria also present
- Bleeding = from the gums and haematemesis
Diagnosis = ELISA testing
Meningococcal infection
Risk
esp risk for trekking through nepal + Haj pilgrimage
Hepatitis A
Risk, prevention
Rural and developing area
Declining level of antibodies to Hep A and adults are at special risk
A blood test to Hep A antibodies
Hepatitis A = 2 injections vaccine (given with Hep B usually)
Avoid contaminated food
Which Hepatitis has a high mortality in pregnant women
Hepatitis E
Japanese B encephalitis
Symptoms, Diagnosis, treamtent
Mosquito-borne flavivirus infection
High mortality
Rice paddies and pig farm = high risk
Febrile illness + Vomiting + Stupor
Rabies
Symptoms, Diagnosis, treamtent
Vaccine recommended, can also be given after bite
Wash immediately with soap
Painful bite + paraesthesia + hydrophobia (pain with drinking)
Main causes of infection in returned traveller
Mostly present within 2 weeks (except HIV)
Common infection = malaria, dengue, giardiasis, hepatitis A and B, gonorrhoea or Chlamydia Trachomatis and Helminthic
Non-infectious = DVT and thromboembolism
Investigation on gastrointestinal system
Mild = microscopy and culture
moderate or prolonged (>3 wks) =
- Stool examination (3 specimens) - microscopy, wet preparation and culture
- Faecal multiplex PCR
- Treat Pathogen
Abnorminal discomfort
- Bloating, intestinal hurry and bornorygmi and often followed by diarrhoea
- usually no pathogen in stool
Important Signs
- Maculopapular - genue, HIV, typhus, syphillis, arbovirus infection, leptospirosis, Q fever
- Petechiae - viral haemorrhagic fever, leptospirosis, dengue
- Rose spot - Typhoid
- Eschar - Typhus (tick and scrub), anthrax
- Chancre - African Trypanosomiasis, syphillis
- Fever - think malaria
Treatment for malaria
- Admit to hospital with infecious disease - rule out G6PD deficiency
- Fluid replacement
- P. vivax, P. ovale, P. malariae - artemether + lumefantrine + primaquine
- P. falciparum - Riamet or quinine + doxycycline / clindamycin
Typhoid fever
Symptoms, Diagnosis, treamtent
Incubation - 10-14 days
- Headache predominates
- Stepladder fever + Abdominal pain (w/ constipation) + relative bradycardia
- Pea soup diarrhoes
- Rose spot rash (later)
Diagonosis - Blood/stool culture, (serology not helpful)
Treatment - Azithromycin or Ciprofloxacin
Cholera
Symptoms, Diagnosis, treamtent
Incudates hours to 5 days
Clinical variable fever + abrupt onset ‘rice water’ diarrhoea
- Causes - electrolyte depletion, intense thirst, oliguira, weakness, shrunken eyes
Diagnosis = Stool microscopy and culture (Vibrio Cholerae)
Treatment
- Strict barrier nursing
- IV fluid and electrolytes
- Doxycycline
Dengue Fever
Symptoms, Diagnosis, treamtent
- sout-east pacific and queensland
- Myalgia and fever <39 dengue > malaria
- Fever + severe aching + rash
Symptoms = abrupt fever, headache, nausea, pain behind eye, severe backache, prostration, sore throat, aching muscles and joing
- subsides in 2 days and then returns
- Maculopapular rubelliform rash on limb or petechial rask
Diagonsis - IgM serology (dengue specific, best on 5 days); PCR; FBE: leukopenia, thrombocytopenia in haemorrhagic form
Treatment - Rest, fluid, analgesics
AVOID antibiotics and corticosteriods
Differentials for fever in returned traveller
Malaria
Dengue (rash)
Chikungunya
Encepalitis (delium, convulsion, coma)
Melioidosis (pneumonia)
Chlorea (rice-water diarrhoea)
Typhoid (stepladder fever + bradycardia)
Clinical Features of uncontrolled diabetes
- Polyuria
- Polydipsia
- Loss of weight (Type 1)
- tiredness and Fatigue
- Propensity for infection - skin and gential (vaginal thrush)
- Vulvovaginitis (inflammation and irritation of vagina)
- Pruritus Vulvae (itchy valva)
- Balanitis (inflammation of head of penis)
- nocturnal enuresis (type 1)
- Blurred vision/visual changes
Secondary causes of diabetes
Endocrine disorder
- Cushing Syndrome
- Acromegly
- Phaeochromocytoma
- polycyctic ovarian syndrome
Pancreatic disorder
- Haemochromatosis
- Chronic pancreatitis
Drug induced
- Thiazide diuretics
- Oestrogen therapy (high dose)
- Corticosteriods
Other transient causes
- Gestational diabetes
- Medical or surgical stress