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Pharmacy > 301 Radiopharmaceuticals > Flashcards

301 Radiopharmaceuticals Flashcards

1
Q

What is an atomic number?

A

Number of protons

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2
Q

What is a mass number?

A

Number of protons (Z) + number of neutrons (N)

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3
Q

What is isotope stability dependent on?

A

Nucleus stability

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4
Q

What is nucleus stability dependent on?

A

No. of protons and neutrons
Nuclear binding energy and mass defect

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5
Q

What is the “shell model” of nucleus stability?

A

If arranged shells are full then they are stable

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6
Q

What are magic numbers?

A

Shell is full = 2, 8, 20, 28, 50, 82, 126 - so not likely radioactive
Magic numbers can refer to either protons or neutrons or both

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7
Q

Isotopes with magic numbers

A

Either protons or neutrons have higher nuclear binding energy and therefore more stable than other, non-magic isotopes

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8
Q

What are doubly magic nuclei?

A

Both proton and neutron shells are full, making binding even stronger

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9
Q

Examples of doubly magic nuclides

A

4He (2+2) is one of most stable and abundant nuclei in universe
208Pb (82+126) is heaviest stable nuclide

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10
Q

What are no-magic isotopes?

A

Even numbers of nucleons promotes stability (even-even nuclei) (6P and Ns)
High (neutron : proton) (N/Z) ratio promotes instability - 238 92 U (92P and 146N) (highest N/Z ratio and so most unstable and radioactive)
1.5 ratio is border between stable and unstable (neutron : proton)

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11
Q

What is nuclear binding energy?

A

Keep protons and neutrons (nucleons) together (protons have repulsive nature)
To separate a nucleon completely, input energy equivalent to nuclear binding energy is needed
The energy required to split a nucleus of an atom into component parts: protons and neutrons

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12
Q

What do higher binding energies do?

A

Greater isotope stability, approx. 6-9 MeV per single nucleon

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13
Q

What is the difference between a nucleon and a separated nuclei?

A

Energy has a mass
The actual total mass of nucleus is always less than theoretical total mass of nucleus

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14
Q

What is mass defect?

A

Difference in mass of atom and sum of masses protons and neutrons
Assess stability of isotope
Difference in mass defect = nuclear binding energy

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15
Q

What will unstable isotopes do?

A

Unstable isotopes will revert to more stable isotopes by emitting radioactivity

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16
Q

What does a high mass defect value indicate?

A

More stable nucleons (high nuclear binding energy) means nucleus has high binding energy and so it is more stable

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17
Q

What are particulate and non-particulate (waves) radioactivity?

A
  1. Alpha and beta (+ and -) radiation
  2. Gamma and X rays
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18
Q

Alpha particle radioactivity

A

Occurs in heavy nuclei
Daughter nuclide has atomic number 2 less than parent (lose 2P) & mass number 4 less than parent (loses 2P and 2N)
Slow, weak penetration (paper) and high ionisation due to +2 charge (wants to attract)

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19
Q

Beta (-) particle radioactivity

A

Occurs in “neutron rich” nuclei (high P)
Neutron breaks down into proton, electron & anti-neutrino
Daughter nuclide atomic number 1 more than parent (create P), mass number same as parent (rid of N and form P)
Faster, better penetration (small particle) (stopped by 0.5cm aluminium sheet), ionisation not as strong as -1 over +2

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20
Q

Properties of anti-neutrino

A

No mass and no charge

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21
Q

Why is beta (-) lighter than alpha?

A

Has 1 electron over 2P and 2N

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22
Q

Beta (+) particle [Positron emission] radioactivity

A

Occur in relatively “neutron poor) (higher P)
Converts P breaks down to N, positive charge released (+1) as positron with a neutrino
Daughter nuclide has atomic number 1 less than parent (P to N change), mass number same as parent (conversion)
Beta (+) has same properties as (-)

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23
Q

What is a positron?

A

Positively charged electron

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24
Q

Do gamma and X rays have charge or mass?

A

No, not particles

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25
Q

Properties of electromagnetic radiation

A

No mass
No charge
Photons of high energy (speed of light)
Short wavelength (means radiation has high energy being short)

26
Q

Gamma radioactivity

A

Occurs in excited metastable (m) state (higher energy) above ground isomeric state (normal)
Daughter nuclide has same atomic and mass number (no particles)
Speed of light so fast, high penetration (lead), ionisation less due to no particles

27
Q

When do metastable nuclei revert to isomeric state?

A

Always, by releasing gamma energy/radiation to relax to isomeric with no particle release

28
Q

X ray radioactivity

A

Occurs in relatively “neutron poor” (high P) nuclei
Electron capture when K1 shell is captured by nucleus
Daughter nuclide has atomic number 1 less parent (P reacts w/ E to make N) & mass number stays same, (P to N)

29
Q

Bremsstrahlung (production of X rays - braking radiation)

A

Electron attracted by nucleus, pulling closer & loses speed, deflecting electron, losing energy & released as X ray
Produced as 2ndary radiation when electron is deflected by mass & charge of nucleus
Electrons lose speed (braking) [Bremsen] & their excess energy is released as X ray radiation (Strahlung)

30
Q

2 cases of X ray production (Bremsstrahlung)

A
  1. Close proximity so released X ray has high energy
  2. Passes further away so less attraction and so less energy released
31
Q

Alpha particles

A

Short range (heavy)
0.03mm in body tissues
Stopped by few sheets of paper

32
Q

Beta particles

A

Short range but further than alpha
1mm in tissue
Stopped by 0.5cm aluminium

33
Q

Gamma rays and X rays

A

Long range
70cm in water
Penetrates lead - need thick shielding (around ovaries)

34
Q

Why does lead stop gamma rays?

A

Dense nuclei

35
Q

What happens with ionising radiation on the body?

A

Loses energy through collision as it goes through body tissues cause localised heating
Creates ion pairs when going through tissue, will cause damage of DNA and cell deaths

36
Q

Tissue damage from within or outside

A

W: problem with alpha & beta
Less an issue with gamma & X rays
O: less an issue with alpha & beta
Problem with gamma & X rays

37
Q

What radiations are used for diagnosis and which to treat?

A

Gamma & X rays for diagnosis
Alpha & beta to treat

38
Q

How do we use beta radiation in cancer treatment?

A

Injection or ingestion destroy cancer cells due to penetration range

39
Q

What order is radioactive decay?

A

1st (exponential decay)
rate of decay (proportionate to) no. of radioactive atoms
High nuclei means higher rate of radioactive decay

40
Q

Rate law

A

R (proportionate to) N
So, R = kN
k being constant
R = rate of decay
N = no. of radioactive nuclei

41
Q

Integrated rate law
lnN(t) = ln N(0) - k x t

A

N0 = no. radioactive nuclei at t = 0
Nt = no. of radioactive nuclei at time = t

42
Q

Half life
t1/2 = 0.693/k
(k= 0.693/t1/2)

A

t1/2 = time for half radioactive nuclei present to decay
Works out nuclei after half-life or figure out half-life

43
Q

Examples of gamma and beta decay mode

A

Iodine-131
Used for treatment of thyroid conditions

44
Q

Examples of gamma decay mode

A

Technetium-99m
Indium-111
Used for diagnostic imaging

45
Q

What is nuclear medicine?

A

Medical modality that utilises radioactivity (radiopharmaceuticals) to diagnose and treat disease

46
Q

What is radiopharmaceuticals?

A

Preparations of constant composition, radiochemical, radionuclidic purity & uniformity of physiological action for nuclear medicine use as diagnostic or therapeutic agents

47
Q

Radiography vs Nuclear medicine

A

R: radiation outside of body to diagnose to see organ function with X rays
NM: radiation within body, inject or ingest to treat (beta emitter) or diagnose (gamma emitter) - use gamma rays

48
Q

What is the optimum dose of a radiopharmaceutical?

A

Which treat/diagnose with least amount of radiation dose or exposure to patient

49
Q

What is a radionuclide in radiopharmaceuticals?

A

Tagged onto chosen pharmaceutical so after admin. of radiopharmaceutical, radiations emitted from it are detected by radiation detector so organ is assessed

50
Q

Radiopharmaceuticals applications: diagnostic images

A

Radionuclide short half-life and emits only gamma radiation
Tc-99m: example
Half life is 6 hours and gamma emission 140KeV ideal for diagnostic imaging

51
Q

Radiopharmaceuticals applications: therapeutic use

A

Radionuclides should emit particulate radiation (beta particles) which deposits radiation within target organ
Iodine-131 used for hyperthyroidism & metastatic disease of thyroid eradication
Emits both beta and gamma radiation to diagnose and therapeutic

52
Q

What is theranostics?

A

Form of precision medicine that combines radioactive materials (radioisotopes) with molecules designed to target cancer cells

53
Q

Becquerel (Bq)

A

1Bq = 1 radioactive decay per second

54
Q

Curie (Ci)

A

1 Curie = 37 GBq
Radiopharmaceutical doses are dispensed to patients in units of activity so mCi or µCi

55
Q

Gray (Gy) = 1J/kg

A

Measure of how much energy from radiation has been deposited in body (absorbed dose)
1 Gy = 1J absorbed by 1kg of tissue

56
Q

Sievert (Sv) = 1J/kg

A

Same as Gy but different interpretation
Equivalent dose (Sv) = absorbed dose (Gy) x radiation weighting factor (Q)

57
Q

What does radiation weighting factor depend on?

A

Radiation type and tissue type & distance

58
Q

Production of radionuclides: cyclotron

A

Daughter nuclide is relatively neutron-poor, decays beta + emission or X rays

59
Q

Production of radionuclides: nuclear reactor

A

Daughter nuclides usually neutron-rich, decay by beta emission (iodine-131 produced by nuclear fission of uranium-235 in nuclear reactors

60
Q

Production of radionuclides: generator

A

Used in hospital for Tc-99m production, emits gamma radiation

Pharmacy (23 decks)

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