3.0 Autonomic Physiology Flashcards
What receptor is found on both parasympathetic and sympathetic post-ganglionic cells? What neurotransmitter is used?
Nicotinic cholinergic receptors and acetylcholine
What kind of receptors are found on the target organs of parasympathetic fibers? What neurotransmitter is used?
Muscarinic cholinergic receptors and acetylcholine
What is the role of M1R?
Salivary gland activation and acid secreting in stomach
What is the role of M3R?
Smooth muscle cell contraction and exocrine gland secretion
What is the role of M2R?
Slow heart rate
What kind of receptors are found on the target organs of sympathetic fibers? What neurotransmitter is used?
Adrenergic receptors and norepinephrine
What is the role of Alpha-1 adrenergic receptors? What kind of receptors are they?
Gq/11 coupled. Leads to smooth muscle vessel contraction, glycogenolysis, gluconeogenesis, lipolysis, lacrimal gland secreation, and contraction of pupils.
What is the role of Alpha-2 adrenergic receptors? What kind of receptors are they?
Gi/o coupled. Leads to contraction of GI sphincters, increased glucagon, smooth muscle vessel dilation, and increased platelets.
What is the role of Beta-1 adrenergic receptors? What kind of receptors are they?
Gs- coupled. Leads to increased heart rate and ventricular muscle contraction (increased BP). Also leads to salivary gland activation and lipolysis.
What is the role of Beta-2 adrenergic receptors? What kind of receptors are they?
Gs- coupled. Leads to bronchiole relaxation, GI relaxation, urinary relaxation, vascular smooth muscle relaxation, and flattening of lens.
What is the role of Beta-3 adrenergic receptors? What kind of receptors are they?
Gs- coupled. Leads to lipolysis in white adipose tissue and heat production in brown adipose tissue.
