30. Adaptations to training- Skeletal muscle Flashcards
Discuss the prenatal development of muscle fibres?
Starts as a Dermomyotome -PAX3 and 7
Embryonnoic myoblasts/ fetal myoblasts/ satellite cells
Type 1 fibres (provide scaffold for) Type 2 fibres
What can be said about muscle fibres from birth
They cannot change in number or proportion
How does cross sectional area and fibre length of muscle fibres change after birth
They increase
How do satellite cells contribute to ageing
They dont
How do myonuclei increase?
In response to steroids or overload
If you have large amounts of myonuclei what happens after de-training?
They can re-increase in number very quickly
How are muscles repaired after trianing
What types of movement are more likely to injure muscles?
Myonuclei repeair muscles. Migrate towards damage and deliver mRNA for synthesis of proteins
Eccentric contractions are more likely to damage
How are micronuclei signalled to repair muscle?
Trigger a signallign cascade including Cdc42 and phosphokinase C
What are the role of satelite cells
Provide myonuclei for growth postnatally
How does motor neuron size affect its ability to send an action potential?
Smaller motor neurons reach an action potential quicker in response to stimulation
What is henneman’s size principle?
At lower effort only small motor neurons will be activated
At higher effort all motor neurons wil be activated
What consequences does the hennemans principle have?
Fibres that are not recruited do not get adaptation inducing stimulus reuired for the shift in balance between synthesis and breakdown
What can be said about how to generate increased force with exercise training?
High resistance and high effort allows for quicker increases in generation of force (90% of one rep max)
What is meant by skinning muscle?
Denature proteins in the sarcolemma to allow various usbstances to pass into the muscle
Muscle fibres are fixed between two rods at optimumk length
How do you calculate if fibres are kept at optimum length?
How do skinned muscle fibres contracted
Measure sarcomere length under microscope
When exposed to high calcium concentrations