3. Vagina Flashcards
1
Q
Diseases of the vagina
A
- Congenital anomalies
- Vaginal intraepithelial neoplasia (VAIN)
- Clear cell adenocarcinoma of the vagina
- Embryonal rhabdomyosarcoma (Sarcoma Botryoides)
2
Q
Etiology of vaginal cancer
A
same as vulvar neoplasia (e.g., HPV 16 and 18)
3
Q
Subtypes of vaginal cancer
A
- Squamous cell carcinoma
- Clear cell adenocarcinoma
- Sarcoma botryoides
4
Q
Squamous cell carcinoma of the vagina
A
- Most common type
2. Usually occurs secondary to cervical squamous cell carcinoma, primary carcinoma is rare
5
Q
Clear cell adenocarcinoma
A
- Usually occurs secondary to vaginal adenosis (the presence of glandular columnar epithelium within the upper two-thirds of the vaginal wall)
- Seen in daughters of women who received diethylstilbestrol during pregnancy
6
Q
Sarcoma botryoides
A
Rare, highly malignant embryonal rhabdomyosarcoma that arises most commonly, but not exclusively in the genitourinary system
7
Q
Epidemiology of sarcoma botryoides
A
Peak incidence in childhood (< 4 years)
8
Q
Pathology of sarcoma botryoides
A
- Gross: clear, polypoid masses that resemble a bunch of grapes protruding through the vagina
- Microscopy: pleomorphic spindle-shaped cells
- Immunohistochemical staining: desmin positive
9
Q
Symptoms of vaginal cancer
A
- Vaginal bleeding
- Leukoplakia, vaginal ulceration with contact bleeding
- Malodorous discharge
- Possibly urinary frequency