3. Vagina Flashcards

1
Q

Diseases of the vagina

A
  1. Congenital anomalies
  2. Vaginal intraepithelial neoplasia (VAIN)
  3. Clear cell adenocarcinoma of the vagina
  4. Embryonal rhabdomyosarcoma (Sarcoma Botryoides)
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2
Q

Etiology of vaginal cancer

A

same as vulvar neoplasia (e.g., HPV 16 and 18)

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3
Q

Subtypes of vaginal cancer

A
  1. Squamous cell carcinoma
  2. Clear cell adenocarcinoma
  3. Sarcoma botryoides
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4
Q

Squamous cell carcinoma of the vagina

A
  1. Most common type

2. Usually occurs secondary to cervical squamous cell carcinoma, primary carcinoma is rare

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5
Q

Clear cell adenocarcinoma

A
  1. Usually occurs secondary to vaginal adenosis (the presence of glandular columnar epithelium within the upper two-thirds of the vaginal wall)
  2. Seen in daughters of women who received diethylstilbestrol during pregnancy
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6
Q

Sarcoma botryoides

A

Rare, highly malignant embryonal rhabdomyosarcoma that arises most commonly, but not exclusively in the genitourinary system

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7
Q

Epidemiology of sarcoma botryoides

A

Peak incidence in childhood (< 4 years)

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8
Q

Pathology of sarcoma botryoides

A
  1. Gross: clear, polypoid masses that resemble a bunch of grapes protruding through the vagina
  2. Microscopy: pleomorphic spindle-shaped cells
  3. Immunohistochemical staining: desmin positive
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9
Q

Symptoms of vaginal cancer

A
  1. Vaginal bleeding
  2. Leukoplakia, vaginal ulceration with contact bleeding
  3. Malodorous discharge
  4. Possibly urinary frequency
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