3 The Role of Nitrogen in Drug Molecules Flashcards
1
Q
What does Ka mean?
A
Acid dissociation constant
2
Q
stronger acid = ____ pKa
A
lower
3
Q
What does Keq»0 indicate?
A
a favourable reaction
4
Q
What can be used to predict ionisation?
A
pKa tables
5
Q
Are arylamines (e.g. aniline) more or less basic than alkylamines?
A
less - so they are less available to bond with H+
6
Q
What are free amine bases?
A
uncharged organic molecules - not very water soluble
7
Q
What are quaternary ammonium salts?
e.g. hydrochlorides, hydrobromides, carboxylates etc.
A
charged organic molecules - relatively water soluble
