3: Sjogrens

Question 1

What is sjogrens disease

Answer 1

Chronic inflammatory disorder marked by lymphocyte infiltration of exocrine glands

Question 2

In which population is sjogrens stereotypically found

Answer 2

Middle-age females

Question 3

What gene is present in 85% of sjogrens

Answer 3

HLA DRW52

Question 4

What is sicca syndrome

Answer 4

Symptoms sjogre’s in absence of disease

Question 5

What is secondary sjogrens

Answer 5

sjogrn’s associated with autoimmune disease

Question 6

what diseases may sjogre’s disease be associated with

Answer 6

RA
SLE
Systemic sclerosis 
Polymyositis 
Primary biliary cirrhosis

Question 7

what disorders are sjogren’s associated with

Answer 7

other autoimmune disorders

Question 8

what is sicca syndrome

Answer 8

dry eyes and dry mouth

Question 9

what are general symptoms of sjogren’s

Answer 9

• Fatigue
• Arthralgia
• Raynaud’s

Question 10

what classification is used to diagnose sjogrens

Answer 10

American-European Consensus Group (AECG)

Question 11

what 6 criteria to AECG state is required to diagnose sjogrens

Answer 11

1. Dry mouth
2. Dry eyes
3. Objective ocular dryness
4. Objective oral dryness
5. Positive anti-ro and anti-La
6. Labial gland focus score over-1

Question 12

what two scoring systems can be used to assess ocular dryness

Answer 12

Schiermer’s test

Bijsterveld score

Question 13

what is the schirmer’s test

Answer 13

Determines if the eye produces enough tears to keep it moist

Question 14

what is a negative schemer’s test

Answer 14

More than 10mm in 5-minutes

Question 15

what schirmer’s test indicates sjogrens

Answer 15

less than 5mm moisture in 5-minutes

Question 16

what antibodies are associated with sjogrens

Answer 16

Anti-Ro (SSA)

Anti-La (SSB)

Question 17

what % sjogren’s have anti-Ro

Answer 17

70

Question 18

what % sjogren’s have anti-La

Answer 18

30

Question 19

what other antibodies are positive in sjogren’s

Answer 19

ANA and RF

Question 20

what is the problem with ANA and RF

Answer 20

Non-specific

Question 21

where may a biopsy be taken in sjogren’s

Answer 21

Lip or salivary gland

Question 22

what may a biopsy of the lip or salivary gland show

Answer 22

Lymphocytic infiltration

Question 23

how is sjogre’s managed

Answer 23

• Artificial tears

- Pilocarpine

Question 24

what stain is used to assess for eye damage in sjogrens

Answer 24

Rose bengal stain