3. Muscular System Pathologies Flashcards

1
Q

Muscle fatigue

A

Muscle fibres can fatigue if overused.

Common in sports, occupational overuse and poor posture.

Associated with a depletion of metabolic reserve. Cell respiration becomes anaerobic and by-products that can cause pain (lactic acid) are produced

It is essential to prevent poor posture and provide muscles with the time needed to rest. Meditation, relaxation exercises, yoga, pilates, essential oils, manual therapy, acupuncture, nutrition e.g. magnesium, herbs and homeopathy can support this.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Muscle shortening

A

If a muscle is continuously contracted, the actin-myosin filaments remain attached.

Chronic muscle contracture causes muscle fatigue but also places a strain on the skeletal muscle attachments.

e.g. a ‘stressed’ individual commonly sustains prolonged contraction of the upper trapezius muscle fibres. As this muscle attaches to the cervical vertebrae, this may cause a strain of these joints and possibly produce a headache.

Muscles require magnesium to break the actin-myosin bond.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Muscle strain

A

Over-stretching of muscle fibrils or the tendon, occurring when a joint is forced beyond its normal range (pulled muscle).

The muscle remains whole and blood supply intact to permit healing

Leg and back strains are common

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Muscle tear

A

Where the muscle tears and is no longer whole. More likely to produce bruising.

Preventing natural complete healing. Can lead to fibrosis.

A tear is suggested if movement is not possible.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Muscle strain and tear treatments

A

RICE - Would you always rice?

Herbal medicine (inflammation, pain, connection tissue repair), Acupuncture, homeopathy (arnica), nutritional support (anti-inflammatory and tissue repair).

If torn: avoid heat, rest initially, exercise, massage.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Impingement syndrome

A

Impingement syndrome describes a shoulder condition in which movements of the shoulder can be painful and limited.

The rotator cuff tendons and/or bursa can become inflamed / damaged. Most noticeable when compressing the space that they are both found within (sub-acromial space - the area between the humeral head and acromion).

The rotator cuff tendons connect the humerus and scapula. Normally, when moving the shoulder, the rotator cuff has to manoeuvre intricately in order to prevent impingement.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Causes of impingement syndrome

A
  • Overuse and working with the arms raised overhead
  • More common with increasing age as blood supply is poor and the tendons degenerate
  • Positional fault - when the head of the humerus does not sit well in the socket
  • Bone spurs - can reduce the space available for the bursa and tendons to move under the acromion
  • Oddly-sized acromion resulting in reduced space
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Signs and symptoms of impingement syndrome

A
  • Shoulder ache in early stages
  • Pain when abducting the shoulder or rotating (i.e. reaching into back pocket)
  • Painful arc of movement
  • A catching sensation is felt on lowering the arm
  • Weakness and inability to raise the arm may indicate rotator cuff tear
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Impingement syndrome tretment

A

Allopathic treatment:
Cortisone injection, NSAIDs, surgery

Natural treatment:
Herbal medicine, acupuncture, homeopathy (arnica), nutritional support (anti-inflammatory), osteopathy, chiropractic, exercise, essential oils (peppermint, frankincense)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Fibromyalgia

A

Fibromyalgia is a chronic pain disorder, heavily associated with widespread musculoskeletal pain and fatigue

Often accompanied by multiple, unexplained symptoms of anxiety, depression and functional impairment of daily activities

Women are 10X more commonly affected than men - mostly occurring age 30-50

Has a neurophysiologic basis, characterised by abnormalities in pain processing by the central nervous system (CNS)

A form of ‘central sensitisation’ - pain perception to sensory stimuli that would not normally be painful

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Fibromyalgia: Pain Processing

A

Fibromyalgia is associated with central sensitisation - a central disturbance in pain processing

Normally, sensory input such as light touch and temperature is sent as nerve signals to the brain / spinal cord where it synapses with nerves

In fibromyalgia, alterations occur in pain processing in the spinal cord and brain (centrally)

High levels of substance P are found in synapses - this makes nerves more sensitised to pain

Excess post-synaptic nitric oxide production also causes the synapses to amplify pain signals.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fibromyalgia: causes and triggers

A
  • poor mitochondrial functioning damaged by free radicals
  • altered stress response (i.e. excess cortisol, adrenal fatigue)
  • post-viral and chronic toxic load e.g. heavy meals, chemicals
  • poor gut health - dysbiosis, leaky gut syndrome
  • serotonin and noradrenaline deficiencies play a role in pain tolerance
  • sleep dysregulation (fatigue, ↑pain, ↓activity).
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Fibromyalgia: signs and symptoms

A
  • widespread (diffuse) musculoskeletal pain
  • pain that results from gentle pressure
  • feeling of swollen joints, often with no actual swelling
  • debilitating fatigue and severely-disturbed sleep
  • headaches (muscular or migraines)
  • IBS symptoms, numbness, tingling and weakness
  • anxiety and depression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Fibromyalgia: diagnosis

A

Criteria for diagnosis: Excess pain on palpation in at least 11 of 18 predefined anatomical points.

The patient experiences pain at tender points at a decreased threshold. However:
• Normal biopsy.
• Normal electrical muscle tests. • Drug studies show no benefit
of NSAIDs but benefits of
antidepressants.

• It is also an ‘exclusion diagnosis’.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Fibromyalgia: treatment

A

ALLOPATHIC TREATMENT:
•Medications, e.g. pain relief. Pain clinics.

NATURAL TREATMENT:
•Gut — checking for dysbiosis, parasites etc. Digestive support.
• Detox — supporting the liver, removing heavy metals and
chemical exposures, limiting EMF exposure, castor oil (liver).
• Mitochondrial support — CoQ10, antioxidants,
magnesium malate, B vitamins, essential fats.
• Reducing stress — nervine herbs (e.g.
passionflower and valerian); breathing exercises.
• Acupuncture, homeopathy.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Muscular Dystrophies

A

Muscular dystrophies are a group of inherited muscular diseases that cause muscle degeneration and weakness.

Muscular dystrophies are characterised by:

  • Progressive skeletal muscle atrophy.
  • Death of muscle cells and tissue (final stages).
  • Defects in muscle proteins.
17
Q

Myasthenia Gravis

A

Myasthenia gravis is an autoimmune disease of the neuromuscular junction, characterised by fluctuating muscle fatigue and weakness.

Antibodies block acetylcholine receptors on the motor end plate preventing a nerve impulse being sent to muscle fibres. The muscle becomes progressively weaker.

Most common in women, age 20‒50.

Muscles of face and neck are commonly affected.

18
Q

Myasthenia gravis: signs and symptoms

A
  • Weakness of ocular muscles; double vision and ptosis.
  • Weakness in facial muscles (expressions) which spreads to the proximal limbs.
  • Difficulty with speech, chewing, swallowing.
  • Death may result from failure of the respiratory muscles.
  • Symptoms worsen throughout the day.
19
Q

Myasthenia gravis: treatment

A

ALLOPATHIC TREATMENT:
• Acetylcholinesterase inhibitors, corticosteroids
to reduce effects of the antibodies.

• Plasma exchange in severe cases; injections
of normal immunoglobulins from healthy donors.

NATURAL TREATMENT:
• Herbal medicine (immune modulation), acupuncture, homeopathy, nutritional (nerve and muscular function) — calcium, magnesium.

20
Q

Duchenne Muscular Dystrophy

A

Caused by a single gene defect on the X- chromosome, affecting males, whilst females can be carriers. Affects 1 in 3500 males.

  • Usually diagnosed three‒five years of age.
  • Associated with a lack of a protein called ‘dystrophin’ in muscle cells. Dystrophin anchors the cytoskeleton to the extracellular matrix.
  • If this protein is missing, when the cell contracts there is no support and the cell membrane becomes leaky, allowing materials to flood in.
  • This results in muscle degeneration and necrosis.
  • All muscle types affected: Skeletal, smooth and cardiac.
  • Small amounts of dystrophin also present in nerve cells (IQ is affected).
  • Prognosis poor: Usually wheelchair support needed by 10 years and ventilation by 20 years.
  • Most die in their late twenties, often from pneumonia and cardio-respiratory failure.
21
Q

Duchenne Muscular Dystrophy: signs and symptoms

A
  • Delayed walking.
  • Difficulty getting up from sitting or lying position.
  • Clumsiness, frequent falls.
  • Waddling gait.
  • Speech delay.
  • Gowers’ sign.
22
Q

Duchenne Muscular Dystrophy: diagnosis

A
  • Serum creatine kinase (10‒100 x normal). This is also often raised in carriers.
  • Genetic analysis and muscle biopsy.
23
Q

Duchenne Muscular Dystrophy: therapeutic strategies

A

prolonging independent walking, managing scoliosis, Nutrition and weight management.