3 MHC And TCR

Question 1

(TP) identify which of the following cells lack MHC-1

A) neutrophils

B) lymphocytes

C) Red Blood Cells

Answer 1

C) red blood cells!!

Question 2

(LO) MHC Class I is ________ and CD_

MHC Class II are ______ and ____ and CD_

Only cells that recognize T-cells are MHC____

Answer 2

…all nucleated cells; CD8

B-Cells and APCs; CD4

MHC II!!!!

Question 3

(LO) Recognize the MHC class I & class II domains responsible for binding
antigen, and the types of antigens presented.

Answer 3

..

Question 4

(LO) Recognize the structure of the T-cell receptor (TCR), and explain the
function of the CD3 complex.

Answer 4

..CD3 required for development and function

Question 5

(LO) Know which type of lymphocytes express CD4, CD8, and CD28

Answer 5

T-cells!!

CD4/MHC-II

CD8/MHC-I

Question 6

(LO) Explain the function of TCR accessory molecules

Answer 6

..important for signal transduction after activation and stabilization

Question 7

(LO) Differentiate the roles of TH1 and TH2 lymphocyte

Answer 7

TH1 promotes CELL mediated responses. Drive Tc cells and NK cells. Release IFNy and TNFB.

TH2 cells promote ANTIBODY-mediated responses. Drives B-cell activation. Release IL-4 and 10

Question 8

What class of MHC is recognized by Cd-4?

Cd-8?

Answer 8

MHC II

MHC I

Question 9

Do red blood cells have any MHC I or II? What about the placenta?

Answer 9

NOOOOOO

No again, not this time placenta

Question 10

Tc cells ______ recognize peptides bound to MHC class I.

Tc cells ____ recognize peptides bound to MHC class II.

Answer 10

CD-8

CD-4

Question 11

MHC Class I has three major loci ________

MHC Class II has three major loci ___________

Answer 11

A, B, C

DP, DQ, DR

Question 12

Why is MHC Class I omnipresent?

Answer 12

Because every cell can become cancerous, get infected by viruses, etc. we need a way to clear the body!!

Question 13

Are endogenous antigens phogocytized?

What presents them?

What are they presented to?

Answer 13

NOT phagocytized

Presented by: MHC I

Presented to: Tc lymphocytes: CD-8

Question 14

Are exogenous antigens phogocytized?

What presents them?

What are they presented to?

Answer 14

YES! Phogocytized material

Presented by MHC II

Presented by Th lymphocytes: CD-4

Question 15

If you see a picture of a MHC class structure, if you see CD-8 coming down with one long streak.. it’s going to be MHC Class _____

Answer 15

MHC Class I structure

A3 is the docking site for CD8

Question 16

If you see a picture of a MHC class structure, if you see CD-4 coming down with two long streaks.. it’s going to be MHC Class _____ .

What’s the docking station for CD4?

Answer 16

MHC CLASS II

A1 and B1 polymorphic and bind to Ag and present to Th cell

B2 is docking station for CD4

Question 17

What’s the portion of an antigen that is bound by an antibody or T-cell receptor? Antigens are covered in these

Answer 17

Epitope!!

Question 18

What’s a substance that can react with an antibody, but CANNOT induce the formation of antibodies unless bound to a carrier protein or other molecule?

Answer 18

Hapten

Question 19

What is the TCR made up of?

The variable region (TOP) binds antigen presented by _______ (all nucleated cells) or by _______ (APCs)

Closely associated with ______ complex and accessory molecules

Answer 19

One A and B chain

MHC-I

MHC-II

CD3

Question 20

What is required for TCR development and function?

Answer 20

CD3

Question 21

Which cells promote CELL-mediated responses? Release?

Which cells promote ANTIBODY-mediated responses? Release?

Answer 21

TH1; IFNy TNFb

TH2; IL-4, IL-10