3. Fluoroquinolones

Question 1

MOA of FQs

Answer 1

Inhibits bacterial DNA topoisomerase IV and DNA gyrase (topoisomerase II) preventing supercoiling of DNA and promotes breakage of double-stranded DNA

Question 2

FQs exhibit [concentration/time]-dependent killing with [bactericidal/bacteriostatic] activity

Answer 2

concentration

bactericidal

Question 3

FQ coverate: ______, _______, and _______ are referred to as the respiratory FQs due to enhanced coverage of ___________ and atypicals

Answer 3

–gemifloxacin, levofloxacin, moxifloxacin

–S. pneumoniae

Question 4

FQ coverage: ________ and _______ have enhanced Gm(–) activity but are typically used in combination with another agent (e.g., a beta-lactam) when treating ________ infections

Answer 4

–ciprofloxacin, levofloxacin

–Pseudomonas

Question 5

FQ coverage: _______ has enhanced Gm(+) and anaerobic activity and can be used alone for mixed infections (intra-______ infections)

Answer 5

–moxofloxacin

–abdominal

Question 6

___________ species have high rates of resistance against FQs and should generally be avoided for treatment of _____

Answer 6

–Staphlococcus

–MRSA

Question 7

ofloxacin (brand, dsoing)

available as tablet, ophthalmic, otic

Answer 7

generic only

200-400 mg