1. Insulins Flashcards

2016 RxPrep p558

1
Q

rapid-acting insulins (4)

A

insulin aspart
insulin glulisine
insulin lispro
inhaled insulin

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2
Q

insulin aspart (brand, available as…)(2)

A

NovoLOG: 100 units/mL

NovoLOG FlexPen: 100 units/mL

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3
Q

insulin glulisine (brand, available as…)(2)

A

Apidra: 100 units/mL

Apidra SoloStar: 100 units/mL

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4
Q

insulin lispro (brand, available as…)(2)

A

HumaLOG: 100 units/mL

HumuLOG KwikPen: 200 units/mL

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5
Q

inhaled insulin (brand, available as…)(1)

A

Afrezza

4, 8, 12 unit cartridges

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6
Q

HumaLOG KwikPen is used when a patient requires >__ units/day of rapid-acting insulin

A

20

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7
Q

Administer rapid-acting insulin up to ___ minutes before or immediately _____ meals; lasts __-__ hrs (shorter than short-acting insulin)

A

15
after
3-5

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8
Q

Afrezza cartridges should be at room temperature for ___ minutes before administration

A

10

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9
Q

Afrezza should be inhaled [before/after] meals; lasts __-__ hrs

A

before

2-3

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10
Q

Replace Afrezza inhaler every ___ days to maintain accurate drug delivery

A

15

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11
Q

Afrezza BBW: CI in patients w/ chronic ____ disease such as ____ or ____. Before initiation, perform a detailed medical history, physical exam and _____ (____) to identify potential ____ disease in all patients.

A

lung
asthma or COPD
spirometry (FEV1)
lung

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12
Q

Afrezza is not recommended in _____ or those who recently ____

A

smokers

quit

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13
Q

Afrezza monitoring

A

pulmonary function tests (FEV1) at baseline, after 6 months, then annually

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14
Q

short-acting or regular insulins (brand) (4)

A

HumuLIN R
NovoLIN R
ReliOn
Humulin R U-500 (available in a 20 mL vial)

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15
Q

All short-acting insulin should be administered ___ minutes before meals; lasts __-__ hrs, and Humulin R U-500 lasts up to ___ hrs

A

30
6-10
24

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16
Q

short-acting insulins [can/can’t] be used in IV solutions

A

can

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17
Q

Humulin R U-500 is 5 times as concentrated and is recommended when the patient requires >____ units/day of short-acting insulin

A

200

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18
Q

Humulin R U-500 [can/can’t] be mixed with other insulins

A

can’t

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19
Q

Dosing formula for U-100 insulin syringe: divide prescribed dose/units of U-500 by __; that is equivalent to the unit markings on a U-100 insulin syringe

A

5

  • the U-500 dose should always be expressed in actual units as well as the corresponding markings on the syringe the patient will be using
  • a conversion chart should be used
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20
Q

Dosing formula for volumetric (tuberculin or allergy) syringe: divide prescribed dose/units of U-500 by __; that is equivalent to the volume (mL) in a volumetric syringe

A

500

  • the U-500 dose should always be expressed in actual units as well as the corresponding markings on the syringe the patient will be using
  • a conversion chart should be used
21
Q

intermediate-acting (NPH) insulins (brand)(3)

A

HumuLIN N
NovoLIN N
ReliOn

22
Q

NPH is given ____ or ____ daily. It contains protamine, making it ____ in appearance.

A

once or twice

cloudy

23
Q

NPH onset is ~__-__ hrs; lasts up to ___ hrs.

A

1-2

24 (varies by patients)

24
Q

NPH [can/can’t] be mixed with rapid and short-acting insulins

A

can

25
Q

When mixing NPH, draw ____ before ____.

A

clear

cloudy

26
Q

long-acting (basal) insulins (3)

A

insulin detemir
insulin glargine
insulin degludec

27
Q

insulin detemir (brand, available as…)

A

Levemir: 100 units/mL

Levemir FlexTouch: 100 units/mL

28
Q

insulin glargine (brand, available as…)

A

Lantus: 100 units/mL
Lantus SoloStar: 100 units/mL
Toujeo SoloStar: 300 units/mL

29
Q

insulin degludec (brand, available as…)

A

Tresiba: 100 units/mL & 200 units/mL pen

30
Q

long-acting insulins are given ____ or ____ daily

A

once (at bedtime)

twice

31
Q

long-acting insulins [can/can’t] be mixed with other insulins

A

can’t

32
Q

_____ has an acidic pH and may sting upon injecting

A

glargine

33
Q

All insulin SEs

A

hypoglycemia, hypokalemia, weight gain, lipodystrophy, injection site reactions

34
Q

How does insulin cause hypokalemia?

A

insulin shifts K+ from the extracellular to intracellular space

35
Q

Use insulin with caution in renal [and/or] hepatic impairment

A

and

36
Q

Insulin pen devices should never be used for more than one person [even/except] when the needle is changed due to ___ __ ______.

A

even

risk of infection

37
Q

insulin monitoring

A

BG, A1C, weight

38
Q

pre-mixed insulins 70/30 (3)

A

NPH/regular
degludec/aspart
aspart protamine susp./aspart sol’n

39
Q

pre-mixed insulin 75/25 and 50/50

A

lispro protamine susp./lispro sol’n

40
Q

70 NPH/30 regular (brand)(3)

A

Humulin 70/30
Novolin 70/30
ReliOn

41
Q

70 degludec/30 aspart (brand)

A

Ryzodeg

42
Q

70 aspart protamine susp./30 aspart sol’n

A

NovoLog Mix 70/30

43
Q

75 lispro protamine susp./25 lispro sol’n

50 lispro protamine susp./50 lispro sol’n

A

Humalog Mix 75/25

Humalog Mix 50/50

44
Q

insulin DDI: meds that also cause hypoglycemia (identify high, moderate, low risk meds)

A

High risk: insulin, pramlintide
Moderate risk: sulfonylureas, meglitinides
Low risk: DPP-4 inh., GLP-1 RA, alpha-glucosidase inhibitors

Management: use caution and/or reduce insulin dose

45
Q

Insulin dosing for T1DM: insulin ___, including ____-_____ and _____ insulins, are preferred to reduce ______ risk and mimic the physiologic pattern of endogenous insulin. It should be started at a total daily dose (TDD) of ___ units/kg/day based on _____ body weight.

A
analogs
rapid-acting
basal
0.6
actual
46
Q

Insulin dosing for T1DM: if using a rapid-acting (bolus) and long-acting (basal) insulin, aka ____-_____ strategy, ___% of the TDD is used as the basal dose and ___% for the bolus dose; the bolus is then further divided among the __ meals.

A

basal-bolus (preferred)
50%
50%
3

47
Q

Insulin dosing for T1DM: if using intermediate-acting NPH and regular insulins, aka ___/__ strategy, ____ of the TDD is used as the NPH dose and ___ as the regular insulin dose; these are generally dosed _____ daily, ___ minutes prior to breakfast and dinner.

A
NPH/R
2/3
1/3
twice
30
48
Q

Insulin dosing for T2DM: _____ insulin is often initiated when patient fails to reach glycemic goals on multiple oral agents and is usually started at __-__ units/kg/day using ____ body weight or ___ units/day.

A

basal
0.1-0.2
actual
10

49
Q

Insulin dosing for T2DM: starting dose is titrated by 10-15% or __-__ units once or twice weekly to reach the fasting blood glucose goal. Would consider 1 to 3 rapid-acting mealtime insulins if ____ glucose levels are normal but ___ remains above goal and would titrate to achieve post-prandial targets.

A

2-4
fasting
A1c