3 Deep Neck Infections Flashcards
What are deep neck space infections?
Deep neck space infections (DNSI) encompass a wide spectrum of infectious disorders of the neck. DNSI are typically classified by the fascial space the infection occupies.
What risk factors are associated with the development of DNSI?
Risk factors of DNSI include
- Low level of education
- Living greater than 1 hour from a tertiary care center
- Presence of tonsils
- Streptococcus infections
- Substance abuse
- Poor dental hygiene
Describe how the neck is organized in terms of fascial planes.
The neck is compartmentalized in two main divisions of fascia: the superficial cervical fascia and the deep cervical fascia.
The superficial cervical fascia includes subcutaneous tissue and envelops the muscles of facial expression. It is continuous with the superficial musculoaponeurotic system (SMAS) and extends inferiorly to involve the platysma.
The deep cervical fascia is divided into superficial, middle, and deep layers.
- The superficial layer invests parotid and submandibular glands, muscles of mastication, trapezius, sternocleidomastoid, and forms the stylomandibular ligament.
- The middle layer is composed of two divisions: the visceral division invests the larynx, pharynx, trachea, esophagus, thyroid, and parathyroid; the muscular division invests the strap muscles.
- The deep layer is composed of two divisions as well: the prevertebral divisionenvelops the paraspinal muscles and vertebrae; the alar division lies atop the prevertebral layer and covers the sympathetic trunk. The carotid sheath represents the confluence of the deep layers of the deep cervical fascia
Identify the deep neck spaces as well as anatomic sites that contribute to the infections within these spaces.
Deep neck spaces can either be suprahyoid, infrahyoid, or span the entire length of the neck. It is important to understand the boundaries of the deep neck spaces because infections often follow these boundaries (or lack thereof) as they spread. DNSI typically are the result of suppuration of lymph nodes from infection at a primary anatomic site.
- Suprahyoid:
- Peritonsillar: tonsil
- Parapharyngeal: tonsil, pharynx
- Submandibular: odontogenic, gingiva, submandibular gland
- Sublingual: odontogenic, gingiva, sublingual gland
- Infrahyoid: visceral
- Span entire length of neck
- Retropharyngeal: nasal cavity, paranasal sinuses, nasopharynx, vertebral bodies
- Prevertebral: hematogenous spread from vertebrae and intervertebral discs
- “Danger” space: parapharyngeal, retropharyngeal space infections
- Carotid sheath: parapharyngeal, retropharyngeal space infections
What conditions can present in a similar fashion to DNSI?
Congenital anomalies can either masquerade as a DNSI or become more clinically apparent when they become infected. Thyroglossal duct cysts, lymphatic malformations, and branchial cleft cysts can rapidly increase in size and present with signs and symptoms identical to DNSI. Prior history of a mass or fullness that waxes and wanes suggests the presence of an underlying congenital lesion.
Neoplastic processes can present with rapid neck swelling and features consistent with an infectious process as well. Fevers, night sweats, and weight loss can be presenting signs of lymphoma. New neck masses in adults are more likely to be malignant when compared to pediatric patients.
What is the “danger space”?
The danger space is bound by the alar fascia anteriorly and the prevertebral fascia posteriorly. It extends from the skull base to the thoracic cavity, providing an unrestricted path for spread of infection into the mediastinum, causing mediastinitis. Infections of the parapharyngeal, retropharyngeal, and prevertebral space can easily extend to this space.
What is the most common major complication of DNSI?
Mediastinitis is the most common major complication of DNSI. It typically presents with tachycardia, dyspnea*, and *pleuritic chest pai*_n. Chest x-ray can demonstrate _*mediastinal widening. Further evaluation with contrast chest CT is necessary to identify fluid collections that require drainage. Broad-spectrum intravenous antibiotics, early consultation with the thoracic surgery service, and close surveillance in the intensive care unit are recommended.
How are prevertebral space infections different from infections of other deep neck spaces?
Prevertebral space infections are generally the result of hematogenous seeding or contiguous spread of infection from discitis or vertebral osteomyelitis.
Gram-positive bacteria, especially Staphylococcus aureus, are the most common pathogens in these infections; anaerobes are uncommon.
What are the most common etiologies of DNSI?
The etiology of DNSI varies with age.
Children: Bacterial pharyngitis and tonsillitis with resultant suppuration of parapharyngeal, retropharyngeal, and jugulodigastric lymph nodes.
Adults: Odontogenic infections; bacteria within dental plaque erode tooth enamel to form periapical abscesses that may penetrate the mandible or maxilla to enter the deep spaces of the neck.
Other etiologies include cellulitis, trauma, foreign body, intravenous drug use, or congenital lesions such as thyroglossal duct cysts or branchial cleft anomalies.
What are the most common pathogens causing deep neck space infections?
Because most of these infections are odontogenic in origin, pathogens are typically part of normal oral flora. These infections are usually polymicrobial, involving a large proportion of anaerobic bacteria, especially as the infections spread into deeper neck spaces. Common bacteria include:
- Streptococcus species
- Peptostreptococcus
- Actinomyces
- Fusobacterium
- Prevotella
More common among immunocompromised hosts, diabetics, and postoperative
- Staphylococcus aureus (including MRSA)
- Pseudomonas aeruginosa
- Other gram-negative rods
What is the role of methicillin-resistant Staphylococcus aureus (MRSA) in deep neck space infections in the United States?
Streptococcal species, particularly group A streptococcus, remain the most common pathogen responsible for nonpurulent skin and soft tissue infections, such as cellulitis and erysipelas.
Purulent skin and soft tissue infections involving the head and neck (abscesses, furuncles, carbuncles, wound infections), on the other hand, are most commonly caused by S. aureus. There has been a dramatic increase in the incidence of MRSA since the early 2000s, particularly community-acquired MRSA among children. Up to 70% of pediatric neck abscesses are due to MRSA in some communities. Patients less than 16 months of age with lateral neck abscesses are 10 times more likely to have aS. aureus infection than non-S. aureus.
What signs and symptoms are common in DNSI?
The most common symptoms are neck pain, fever, dysphagia, neck swelling, and odynophagia. Referred pain resulting in otalgia and odynophagia is also common.
What are the key physical exam findings in the evaluation of a patient with DNSI?
A complete head and neck exam is essential in all patients with DNSI. Initial interview should devote attention to hoarseness, dyspnea, stridor, stertor, muffling or “hot potato” voice. Dysphonia should be evaluated with flexible fiber-optic laryngoscopy for possible airway compromise if the patient is stable.
Inspection and palpation of the head and neck should begin away from the primary site of infection, reserving that portion of the exam for last. Evaluation of the involved area should focus on the size of the area, presence of
- induration
- swelling or fluctuance
- any color change or cellulitic change of the overlying skin. Any cellulitic change should be marked along its periphery to permit accurate surveillance.
- Presence of crepitus suggests infection with gas-producing organisms.
Cranial neuropathies can suggest retrograde spread of infection along the valveless venous system of the midface from soft tissue, nasal cavity, or the paranasal sinus infections.
What is trismus and why is it significant?
Trismus refers to the reduced ability to open the mouth. In the setting of DNSI, it is a sign of inflammation of the parapharyngeal, masseteric, pterygoid, and/or temporal spaces. While seen commonly in odontogenic infections, trismus is also seen with peritonsillar, parapharyngeal, and floor of mouth infections. Severe trismus can lead to difficulty managing secretions and cause airway compromise, presenting challenges for airway intervention should it be needed.
How should suspected deep space neck infections be worked up?
Typical diagnostic workup of DNSI includes complete blood count with differential and radiographic evaluations. Atypical presentations (painless, slow growing, association with weight loss and night sweats) should raise suspicion for malignancy. Atypical infectious etiologies should be evaluated with placement of a PPD with chest x-ray, HIV testing, and titers for Bartonella henselae.
Anterior-posterior and lateral neck plain films are useful in evaluation of the retropharyngeal space (figure below). Ultrasound and computed tomography are the most common radiographic modalities employed when evaluating DNSI. Ultrasound is effective in differentiating cellulitic change from a fluid collection and can also be used for guidance to localize an abscess cavity. Computed tomography with contrast can demonstrate an abscess in the form of a hypodense focus centrally with peripheral rim enhancement.