3. Body fluid compartments Flashcards
What is the main function of the kidney?
regulate the volume and composition of the body fluids within narrow limits
eq for total body water (TBW)
0.6(body weight)
eq for intracellular fluid
0.4(body weight)
eq for extracellular fluid
0.2(body weight)
eq for plasma
0.25(ECF)
eq for interstitial fluid
0.75(ECF)
what are the major ions of the ecf
Na and Cl
what are the major ions of the icf
K and PO4
serum electrolytes:
Na
135-147 mEq/L
serum electrolytes:
Cl
95-105 mEq/L
serum electrolytes:
K
3.5-5.0 mEq/L
serum electrolytes:
Creatinine
0.6-1.2 mg/dL
serum electrolytes:
BUN
7-18 mg/dL
serum electrolytes:
serum osmolality
285-295 mOsm/kg H20
what is the result of ECF volume loss
increased total plasma protein (concentration)
what is the result of ECF volume gain
decreased total plasma protein (dilution)
ECF volume loss will do what to hematocrit
increase
ECF volume gain will do what to hematocrit
decrease
ICF volume loss will do what to hematocrit
decrease
ICF volume gain will do what to hematocrit
increase
Gibbs-Donnan Effect
presence of a negatively charged protein on one side of a semipermeable membrane generates both osmotic and electrochemical gradients across the membrane
what counteracts the inward force created by the Gibbs-Donnan effect?
Na/K ATPase pump
what is responsible for the ECF osmotic balance
Na
what is responsible for the ICF osmotic balance
K
