3 Acids, Bases & Buffers Flashcards

1
Q

Dynamic Equilibrium

A
  1. ) most chemical reactions are reversible
  2. ) reactants combine to give products
  3. ) products can fall apart to give reactants
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2
Q

Le Chatelier’s Principle

A

-when a system in a state of dynamic equilibrium is disturbed (meds), it will react to re-establish equilibrium conditions

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3
Q

The Equilibrium Constant

A
  • a system is in a state of equilibrium when there is a balance between reactants and products
  • mathematical, numerical description of the balance
  • pKa
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4
Q

K

A

state of equillibrium

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5
Q

As K increases…

A

reaction tends to shift towards products

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6
Q

As K decreases..

A

reaction tends to shift towards starting materials

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7
Q

Subscript Keq

A

generic equilibrium constant

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8
Q

Subscript Ka

A

weak acids

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9
Q

Subscript Kb

A

weak bases

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10
Q

Subscript Ksp

A

solubility

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11
Q

Bronstead: Acid

A

-a proton/hydrogen ion donor

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12
Q

Bronstead: Base

A

-a proton/hydrogen ion acceptor

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13
Q

Conjugate Base

A

when an acid donates a proton, it is converted into its conjugate base

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14
Q

Conjugate Acid

A

when a base accepts a proton, is becomes a conjugate acid

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15
Q

Amphoteric Species

A
  • can behave as an acid or a base

- ex.) water

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16
Q

The stronger the acid…

A

the weaker the conjugate base
*more determined to give its proton to some base
“rly pushy

17
Q

The weaker the acid…

A

the stronger the conjugate base

18
Q

ion

A

atom or molecule w/ net electrical charge d/t loss or gain of electrons

19
Q

ionize

A

conversion of an ion by removing ion/ions

20
Q

nonionized

A

uncharged, lipophilic

21
Q

ionized

A

charge, hydrophilic

22
Q

3 steps to determine drug nature

A
  1. ) is the drug weak acid or weak base?
  2. ) what is the pKa of the drug
  3. ) the pH of the target solution
23
Q

Naming weak acids

A

salt drugs - sodium drug, calcium drug, magnesium drug

-salt base form of a weak acid, increased solubility

24
Q

Naming weak bases

A

drug chloride, drug sulfate

-salt form of weak base

25
Q

Weak Acid examples

A

thiopental, sodium phenobarbital

26
Q

Weak Base examples

A

local (lidocaine), morphine, versed

27
Q

Fetal pH

A
  • more acidic

- more likely to trap ions