3 Flashcards

1
Q

What are the functions of the pelvic floor?

A
  • support the pelvic organs (mainly vagina, uterus, ovaries, bladder and rectum)
  • maintain intra-abdominal pressure during coughing, vomiting, sneezing and laughing
  • facilitate defecation and micturition
  • maintain urinary and faecal continence
  • facilitate childbirth
  • breathing
  • sexual function
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2
Q

What are the three mechanisms that help the pelvic floor to support? Define them

A
  • Suspension: maintains an “anti-gravity” position by providing strong vertical support, mainly from the cardinal ligaments and Uterosacral ligaments
  • Attachment: structures piercing the pelvic floor muscles are attached to it, for example the vagina is supported by its attachment to endopelvic fascia, levator ani muscle and the perineal body
  • Fusion: support that arises from fusion of different tissues, for example the urogenital diaphragm and the perineal body, implies link, connection, inseparable
  • Ex: lower half of vagina is supported by fusion of vaginal endopelvic fascia to the perineal body posteriorly, levator ani laterally and urethra anteriorly
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3
Q

Describe the cardinal ligament

A
  • holds the cervix and upper vagina in place

- a transverse ligament that works against gravity

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4
Q

Describe the Uterosacral ligaments

A

-holding the back of the cervix and upper vagina laterally

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5
Q

Describe the round ligament

A
  • maintains the antiverted position of the uterus

- more of a position support

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6
Q

Describe the two fascia that help with attachment

A
  • Argus tendinitis fascia pelvis (AFTP): aka the “white line”
  • Endopelvic fascia: stretches like a hammock from the white line laterally, to the vaginal wall medially
  • urethra lies anterior and above it and, thus, gets compressed against it during increased intra-abd pressure
  • IMPORTANT IN MAINTAING URINARY CONTINENCE (forces urethra to close)
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7
Q

What are the layers of the pelvic floor, from top to bottom?

A
  • Levator ani muscles
  • urogenital diaphragm/perineal membrane
  • perineal body (fusion of all the muscles)
  • perineal muscles
  • posterior compartment
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8
Q

Describe the deep muscles of the pelvic floor

A

-U-shaped set of muscles that act like a sling to encircle the urethra, vagina and rectum, and provide support for these organs
-stretches backwards and inwards from either side of the pelvis to meet in the middle line
-originates from back of the pubic bone, the white line over obturator internus, and medial aspect of ischial spine
-some of the fibres are inserted as they encircle the urethra, some are inserted as they encircle the vagina, where they take part in forming the perineal body
-some fibres are inserted as they encircle the rectum and rest are inserted in the lower part of the coccyx and anococcygeal raphe
THREE MUSCLES: puborectalis (around rectum), pubococcygeus, iliococcygeus

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9
Q

What are the 3 superficial muscles and what is their purpose?

A
  • most commonly involved in perineal trauma-accident, sexual, obstetric
  • Bulbospongiosus, ischiocavernosus, superficial transverse perineal
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10
Q

Describe a medio-lateral episiotomy

A
  • done to avoid damage to the perineal body, b/c of its integral role in providing pelvic floor support as a site of attachment
  • can be done if baby is large or difficult deliver
  • can cause complications such as infection, haemorrhage, dyspareunia and damage to anal sphincter
  • done to prevent perineal damage
  • bulbospongiosus and transverse perineal muscles undergo iatrogenic damage
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11
Q

Describe the perineal body

A
  • central point between the vagina and the rectum
  • main function is to act as a site of attachment for pelvic floor muscles and other structures that provide support for the pelvic floor
  • attached posteriorly to external anal sphincter and the coccyx
  • support of the perineal structures rely on it
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12
Q

Describe the urogenital diaphragm

A
  • Triangular sheet of dense fibrous tissue that spans the anterior half of the pelvic floor
  • also attaches to the urethra, vagina and perineal body
  • arises from the inferior ischiopubic Ramus
  • supports the pelvic floor
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13
Q

What is the blood supply, innervation, venous and lymphatic drainage of the pelvic floor?

A
  • blood supply: internal and external pudendal artery and drains through CORRESPONDING veins
  • lymphatic drainage: inguinal lymph nodes
  • nerve supply: branches of the pudendal nerve which derives its fibres from the ventral branches of the second, third and fourth sacral nerve
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14
Q

Describe pelvic floor dysfunction

A
-wide range of symptoms and conditions that can arise as a result of problems to do with pelvic floor 
Different types:
-Pelvic organ prolapse
-Incontinence: urinary (stress)
-Posterior compartment pelvic floor dysfunction 
-Obstetric trauma including episiotomy 
-FGM
-Vaginismus
-Vulval pain syndromes
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15
Q

What is pelvic organ prolapse?

A
  • loss of support for the uterus, bladder or colon which results of a prolapse of any of these organs into the vagina
  • not life-threatening but has a significant impact on quality of life, perception of body image and can cause depressive symptoms
  • associated with significant function disturbances including: anorectal, urinary, and sexual
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16
Q

What are the POPs in the anterior compartment?

A
  • usually relates to bladder and/or urethra
  • cystoceole: bladder
  • urethrocoele: urethra
  • cystourethrocoele: both
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17
Q

What POP can occur in the middle compartment?

A
  • uterine prolapse
  • procidentia: when ENTIRE uterus prolapses
  • after a hysterectomy: apex may still prolapse which is called POST_HYSTERECTOMY VAULT PROLAPSE
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18
Q

What POP can occur in the posterior compartment?

A
  • rectum may prolapse into the posterior part of the vagina-rectocele
  • loops of bowel may prolapse into the rectovaginal space (pouch of Douglas): enterocele
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19
Q

What are the causes and risk factors of POP?

A
  • age
  • parity
  • mode of delivery (i.e. vaginal delivery)
  • oestrogen deficiency
  • chromic increased abd pressure, obesity
  • connective tissue or neurological disorders (ex. Muscular dystrophy, Marfans)
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20
Q

What type of history and examination would you take for pt’s with POP?

A
  • pt. Will feel a lump down below, or something “coming down”, dragging
  • may also experience constipation if rectal prolapse
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21
Q

How would you manage a pt with POP?

A

Need to consider these factors:
-nature of symptoms and degree of bother
-nature and extent of prolapse
-completion of family and future pregnancy plans
-sexual activity
-fitness for surgery and anaesthesia
-woman’s goals
-work, physical activity and domestic circumstances
Non surgical option: pessaries (holds the pelvis and its organs up between the two bones) including ring, shelf, and gel horn pessaries
Surgical option:
-more definitive treatment
-risk of recurrence and potential complications
-can be performed vaginally, abdominal, laparoscopically
-included anterior/posterior repair, vaginal hysterectomy etc.

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22
Q

Describe Obstetric Anal Sphincter Injuries (OASIS)

A
  • perineal tears involving the anal sphincter complex
  • types: 3rd and 4th degree tears
  • can result in significant morbidity
  • demonstrates the functions of the pelvic floor: continence and support
23
Q

What is an episiotomy?

A

When a cut is surgically made through pelvic floor which will accommodate space for the baby during birth

24
Q

What is vaginismus?

A
  • when pelvic muscles are so taut they keep everything close

- lots of pain when even inserting a tampon

25
Q

How can you prevent OASIS?

A
  • think about episiotomy (risk groups and correct angle) i.e. restrictive use
  • for every 6 degrees the episiotomy is made away from the midline, there is a 50% reduction in third degree tear
  • perineal protection at crowning can be protective
  • encouraging the mother NOT to push when the head is crowning
26
Q

Describe urinary incontinence

A
  • increased abd pressure causing “leaks” of urine as the support to the urethral sphincter is inadequate
  • stress incontinence
  • other types: urge incontinece due to problems with the bladder not the pelvic floor
27
Q

What are risk factors of urinary incontinence?

A
  • same as POP

- particularly age and oestrogen deficiency

28
Q

How would you examine a pt. With urinary incontinece?

A
  • passing urine on coughing, laughing or other activities that increase abd pressure
  • obvious injury to pelvic floor
  • urodynamic studies can be used to investigate further
29
Q

How would you manage a pt. With urinary incontinence?

A
  • pelvic muscle floor training

- surgical intervention can be used to create “slings” to support the urethral sphincter

30
Q

Describe vulval problems

A
  • where pt’s experience pain with on obvious finding on examination
  • often related to tension of levator ani muscles
  • vestibulodynia: painful vulva
  • vaginismus: pain on vaginal penetration due to involuntary muscle spasm
  • assessment and management reflects understanding of the pelvic floor
31
Q

What is Female Genital Mutilation (FGM)?

A
  • all procedures involving partial or total removal of external female genitalia or other injury the to the female genital organs, whether for cultural or other non-therapeutic reasons
  • reasons: religious practice, culture (purification), social acceptance, family honour
  • significant consequences such as severe pain, potential sepsis or haemorrhage
  • potential long term complications include psychological effects, sexual dysfunction, difficulty conceiving, chronic pain, and menstrual disorders, PTSD
  • it is illegal in the UK
  • no offence if cutting is connected to labour and delivery
32
Q

What are the different types of FGM?

A

Type 1: partial or total removal of the clitoris and/or prepuce (clitoridectomy)
Type 2: partial or total removal of the clitoris and labia minors, with or without excision of the labia majora (excision)
Type 3: Narrowing of the vaginal orifice with creation of a covering seal by cutting and appositioning of the labia minors and/or labia majora, with or without excision fo the clitoris (infibulation)
Type 4: all other harmful procedures to the female genitalia for non-medical purposes, ex. Pricking, piercing, incising, scraping and cauterizing

33
Q

Describe posterior compartment pelvic floor dysfunction

A
Presents as:
-vaginal or rectal bulge/lump
-constipation
-incomplete evacuation
-dyssynergic defecation (anismus)
-anal incontinence 
Causes:
-structural (ex. Rectocele, rectal prolapse)
-drugs (ex. Opiates, iron supplements)
-dehydration
-immobility
-pregnancy
-post-op pain
34
Q

Describe anal/faecal incontinence

A
  • involuntary loss of flatus, liquid or solid stools that is a social or hygienic problem
  • causes both physical and psychological distress: lead to significant impairment of quality of life
  • commonest cause of faecal incontinence in women: obstetric anal sphincter injury
35
Q

What is a gamete?

A
  • cells that are responsible for reproduction
  • proliferate by imitosis
  • reshuffle genetically and reduce to haploid by meiosis
  • cytodifferentiate into mature gametes
  • timing and scale varies between sexes
36
Q

What is spermatogenesis?

A
  • for males
  • make about 200 million/day
  • continuous production
  • essentially “disposable” cells
  • occurs in seminiferous tubules of testes
  • initially Spermatogonia resides in basal compartment
  • these divide by mitosis to give two primary spermatocytes
  • one replaces the spermatogonia and one undergoes meiosis 1 to produce two secondary spermatocytes
  • secondary spermatocytes undergo meiosis 2 to produce 2 spermatids each
  • available for up to 70 years
37
Q

What factors contribute to genetic variation?

A
  • crossing over: exchange of regions of DNA between 2 homologous chromosomes
  • independent assortment: random orientation of each bivalve the along the metaphase plate with respect to other bivalents
  • random segregation: random distribution of alleles among the four gametes
38
Q

Describe the basal and adluminal compartment

A
  • basal: where is sperm is initially
  • Sertoli cell barrier splits the two compartments and they contain tight junctions for sperm to pass
  • adluminal: where sperm matures
39
Q

Define ad spermatogonium and AP spermatogonium

A
  • ad spermatogonium: “resting” reserve stock
  • AP spermatogonium: “active”: maintain stock and from puberty onwards produce type B spermatogonia which give rise to primary spermatocytes
40
Q

Describe the spermatogonia cycle and wave

A
  • sperm are in different stages of the cycle so that there is always a mature batch ready
  • cycle: refers to the length of time it takes for spermatids at the same stage in the cycle to “show up” again when looking at a specific point along the seminiferous tubules
  • wave: refers to the distance between groups of spermatids at the same level of maturation
  • each stage follows in an orderly sequence along the length of the tubule
  • waves move in corkscrew like spirals towards the inner part of the lumen
41
Q

Describe spermiogenesis

A
  • process by which spermatids become spermatozoa
  • spermatids release into lumen of seminiferous tubules (spermiation)
  • sperm remodel as they pass down the tubule, through the rete testis and ductili efferentes and into the epididymis to finally form spermatozoa
  • non-motile (transport via Sertoli cell secretions assisted by peristaltic contraction) until they reach epididymis
42
Q

Describe the structure of sperm

A
  • head contains nucleus (genetic info)
  • tail provides motility for sperm
  • mitochondria producing ATP that provide energy to drive the flagella tail allowing motility of sperm
43
Q

How is the sperm delivered?

A
  • through semen (makes up 2ml of ejaculate)
  • seminal vesicle secretionS (about 70%): amino acids, citrate, fructose, prostaglandins (fructose used instead of sucrose to prevent direct competition)
  • secretions of prostate (about 25%): proteolysis enzymes, zinc
  • sperm (via vas deferens) (2-5%): about 200-500 million per ejaculate
  • bulbourethral gland secretions (Cowper gland): mucoproteins help lubricate and neutralize acidic urine in distal urethra (<1%)
44
Q

Which Fallopian tube has better successful fertilization?

A

Right side

45
Q

Describe sperm capacitiation

A
  • when glycoproteins coat and cholesterol on head of sperm is released when in the vagina
  • after removal, sperm is fertile and ready to fertilize ovum
  • allows sperm to bind to zona pellucida of oocyte and initiate acrosome reaction
  • important when thinking about IVF
46
Q

Describe oogenesis

A
  • maturation of oocytes in ovary
  • before birth female has developed her entire stock of potential gametes (oogonia)
  • rapidly divide via mitosis and then enter meiosis 1 and stop at prophase
  • primary oocytes are surrounded by flat epithelia cells (follicular cells) and are termed as primordial follicles
  • cell death (atresia) of oogonia occurs
  • about 40 000 oocytes remain by puberty
  • from puberty onwards about 15-20 oocytes start to mature each month passing through 3 stages (preantral, antral, and preovulatory)
47
Q

What is the preantral stage?

A
  • follicular cells of primordial follicle proliferate to form granulosa cells, which secrete the zona pellucida
  • surrounding follicular cells change from flat to cuboidal and proliferate to produce stratified epithelium of granulosa cells
  • now known as primary follicle
48
Q

What is the antral stage?

A
  • as development of primary follicle continues, fluid filled spaces appear between the granulosa cells
  • these coalesce to form the collective space known as the antrum
  • follicle is now called a secondary follicle
  • granulosa cells surrounding oocyte are called Cumulus oophorus
  • outer fibrous layer develops into theca interna and theca externa
  • theca interna receives LH and FSH to produce androstenedione
  • androstenedione is taken up by granulosa cells to produce oestrogen
49
Q

What is the pre-ovulatory stage?

A
  • surge in LH induces preovulatory growth phase
  • meiosis 1 is now complete resulting in 2 unequally sized haploid cells
  • fully mature one is known as the Graafian follicle
  • Graafian follicle enters meiosis 2 just before ovulation but wont complete meiosis 2 until fertilization occurs
  • if no fertilization then cell degenerates about 24 hours later
50
Q

What happens right after ovulation?

A
  • following ovulation, remaining granulosa and theca interna cells become vascularised, forming the corpus luteum which secretes estrogen and progesterone
  • stimulates uterine mucosa to enter secretory stage in preparation for embryo implantation
  • if no fertilization then corpus luteum degenerates after 14 days
  • when corpus luteum degenerates it forms the corpus alibicans, which is a mass of scar tissue
51
Q

Describe ovulation

A
  • FSH and LH stimulate rapid growth of follicle several days before ovulation occurs
  • mature follicle now about 2.5cm in diameter and called Graafian follicle
  • LH surges collagenase activity
  • prostaglandins increase in response to LH and cause local muscular contractions in ovarian wall
  • oocyte extruded and breaks free from ovary
52
Q

Describe oocyte transport

A
  • shortly before ovulation, Fimbriae sweep over surface of ovary
  • uterine tube begins to contract rhythmically
  • oocyte carried into tube by sweeping movements of fimbriae and by motion of cilia on epithelial lining
  • oocyte then propelled by peristaltic muscular contraction of the tube and by cilia in the mucosa
  • if fertilized, oocyte reaches uterine lumen in about 3-4 days
  • implanted embryo releases HCG which maintains corpus luteum until the placenta takes Over production of progesterone
53
Q

What hormones affect the ovarian cycle?

A
  • under influence of hypothalamic GnRH, anterior pituitary releases FSH, and LH
  • follicles stimulated to grow by FSH and to mature by FSH and LH
  • ovulation occurs on LH surge
  • LH also promotes development of the corpus luteum
54
Q

Compare spermatogenessis and oogenesis

A
  • sperm: 200 million sperm per day
  • ovary: usually 1 ovum per 28 day menstrual cycle (400 in lifetime)
  • sperm: 4 spermatids of equal size, no polar body
  • ovary: one ovum with unequal division, 3 polar bodies
  • sperm: starts at puberty
  • ovary: starts in fetus
  • sperm: continues throughout adult life
  • ovary: ends at menopause
  • sperm: motile gametes
  • ovary: non-motile gametes
  • sperm: all stages complete in testes
  • ovary: last stage of meiosis 2 occurs in oviduct