3 Flashcards
Bisphosphonates
get into bone and incapacitate osteolclast - reduce bone resorption.
Paget’s disease treatment, hypercalcemia, osteoporosis, metastatic bone diesease
bisphosphonates
NSAID
nonsteroidal anti inflammatory drugs
NSAIDS inhibit
biosynth and release of prostaglandins in cells
NSAID side effects
gastrointestinal ulceration, allergic reactions, gastrointestinal and renal toxicity
—— reduce gingival inflammation, but have modest effects on attachment
NSAIDS
Bisphosphonates side effects
osteomalacia, allergic reactions
—— modest effect on bone density, none on attachment loss
bisphosphonates
Periostat
low dose of doxycycline hyclate - 20 1 pill daily for 3 months - tetracycline related therapy
——- concentrates in GCF and uses cementum as reservoir
periostat
——- can increase attachment levels
Periostat
NSAIDS not recommended for perio disease treatment due to
possible site effects
Controlled delivery for drugs is beneficial because
rate control, active over multiple days, active only at site, high concentrations can be used, low overall dose, applied by therapist.
Fibers had to be
removed after use
Carriers for injectable systems are
PLA, PLGA (slow release)