3 Flashcards
Bisphosphonates
get into bone and incapacitate osteolclast - reduce bone resorption.
Paget’s disease treatment, hypercalcemia, osteoporosis, metastatic bone diesease
bisphosphonates
NSAID
nonsteroidal anti inflammatory drugs
NSAIDS inhibit
biosynth and release of prostaglandins in cells
NSAID side effects
gastrointestinal ulceration, allergic reactions, gastrointestinal and renal toxicity
—— reduce gingival inflammation, but have modest effects on attachment
NSAIDS
Bisphosphonates side effects
osteomalacia, allergic reactions
—— modest effect on bone density, none on attachment loss
bisphosphonates
Periostat
low dose of doxycycline hyclate - 20 1 pill daily for 3 months - tetracycline related therapy
——- concentrates in GCF and uses cementum as reservoir
periostat
——- can increase attachment levels
Periostat
NSAIDS not recommended for perio disease treatment due to
possible site effects
Controlled delivery for drugs is beneficial because
rate control, active over multiple days, active only at site, high concentrations can be used, low overall dose, applied by therapist.
Fibers had to be
removed after use
Carriers for injectable systems are
PLA, PLGA (slow release)
Collagen gel carrier with chlorhexidine as active material
periochip
Co polymer carrier with doxycycline as active material
atridox
Like a sand or salt
arestin
Slight to moderate perio patients with limited sites that are unresponsive to non-surgical therapy
Indicated for local antibiotic.
Local antibiotic delivery should be considered as ———– therapy to fSRP for limited sites with _—— probing depths
adjunctive
> =5mm
Allergies to specific antimicrobial reagent
Several sites/mouth with residual periodontal pockets following SRP
Applications without performing SRP
contraindications for local antimicrobial delivery
Root planing opens up ——- where bacteria can live
dentinal tubules
