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MOD exam 1 random flashcards > 3-4 Principle mediators of inflammation > Flashcards

3-4 Principle mediators of inflammation Flashcards

1
Q

Histamine

A

Mast Cells, basophils, platelets

  • vasodilation
  • increased vascular permeability
  • endothelial activation
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2
Q

Prostaglandins

A

Mast cells, leukocytes

  • vasodialtion
  • pain
  • fever
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3
Q

Leukotrienes

A

Mast cells, leukocytes

  • Increased vascular permeability
  • chemotaxis
  • leukocyte adhesion and activation
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4
Q

Cytokines

TNF, IL-1, IL-6

A

Macrophages, endothelial cells, mast cells

Local: endothelial activation

Systemic: fever, metabolic abnormalities, hypotension

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5
Q

Chemokines

A

Leukocytes, activated macrophages

  • chemotaxis
  • leukocyte activation
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6
Q

Platelet Activating Factor

A

Leukocytes, mast cells

  • Vasodilation
  • increased vascular permeability
  • leukocyte adhesion
  • chemotaxis
  • degranulation
  • oxidative burst
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7
Q

Complement

A

plasma

  • leukocyte chemotaxis and activation
  • direct target killing
  • vasodilation
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8
Q

Kinins

A

plasma

  • Increased vascular permeability
  • smooth muscle contraction
  • vasodilation
  • pain
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MOD exam 1 random flashcards (4 decks)

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