3/17 Intestinal Disease - Carman - INCOMPLETE

Question 1

Whipple’s disease

Answer 1

​MALABSORPTION + lymphadenopathy + arthritis + fever + neuro sx

why malabstoption? → impaired lymphatics due to blockage of enterocytes by lipid laden macrophages

• migratory arthralgias
• weight loss
• abd pain
• diarhhea
• ophtalmoplegia, nystagmus, myoclonus

cause: Tropheryni whipplei

dx: small bowel biopsy → macrophages staining PAS+

rx: antibiotics

Question 2

abetalipoproteinemia

Answer 2

pediatric issue

autosomal recessive

GI tract cells lack ability to make apoprotein B (used to build membranes of chylomicrons and lipoproteins)

can’t absorbe fat-soluble vitamins! → deficiency in ADEK

• ataxia
• retinitis pigmentosa
• spinocerebellar degeneration

Question 3

eosinophilic gastroenteritis

Answer 3

eosinophilia…

• NOT assoc with allergy or other cause (parasite, etc)
• NOT present in any other organ

abd pain, n/v, diarrhea, malab, wt loss

biospy: 20+ eosinophils/HPF