2D- Pedigree Analysis

Question 1

Describe the meaning of the symbols used in pedigree charts for male, female, affected, carrier and deceased individuals

Answer 1

Question 2

Describe the arrangement of lines indicating mating, parentage and offspring

Answer 2

Question 3

Be able to use the specific symbols for consanguinity, identical and fraternal twins

Answer 3

Question 4

Be able to construct pedigrees showing autosomal dominant inheritance patterns

Answer 4

Question 5

Be able to construct pedigrees showing autosomal recessive inheritance patterns

Answer 5

Question 6

Distinguish the circumstances in which carriers will or will not be indicated on a pedigree that you must interpret.

Answer 6

Question 7

Determine the Coefficient of Relationship between two first cousins

Answer 7

(1/2)⁴= 1/16 for each cousin

If individuals A and E shared only one grandparent, the coefficient would be 1/16. But since they share a common grandfather and grandmother; two paths through which the disease gene could have traveled.

Therefore we can add up these two paths/probabilities (1st from F and 2nd from C)to get the overall probability that A and E share a disease gene: 1/16 + 1/16 = 1/8