Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MIM 2 > 26. Herpes Virus Infections > Flashcards

26. Herpes Virus Infections Flashcards

1
Q

latent infection

A

in neurons, with later reactivation of a presumably intact virus genome, resulting in a productive infection in mucocutaneous or ocular sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Varicella Zoster initial viral replication is in __

A

the respiratory tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

α-herpesviruses

A

HSV 1, 2 and Varicella Zoster

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

recurrent infections are usually __ painful

A

less

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

β-herpesviruses

A

CMV, HHV 6,7

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

the attack rate for HSV-2 is __

A

75%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

chickenpox is spread by:

A

respiratory and direct contact

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

how do you identify congenital CMV infection?

A

isolating virus from the neonate’s urine during the first week of life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CMV generally causes __ infection

A

subclinical

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

why is shingles life-threatening?

A

more severe disease with potential pneumonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Infectious mononucleosis is characterized by ___ in a peripheral smear. They appear as __

A

atypical lymphocytes, large cells with lobulated nuclei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CMV establishes latency in:

A

B and T cells, and Macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

heterophile (monospot) negative mononucleosis is caused by:

A

CMV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

chickenpox lesions are __

A

polymorphic (papules, vesicles, and crust all seen at once)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

most primary HSV-1 infections are __. However, they can cause __

A

asymptomatic, gingivostomatitis or vulvovaginitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Varicella Zoster secondary infection:

A

zoster/shingles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Herpes genetic structure:

A

double stranded DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

cytomegalic inclusion disease:

A
  • hepatosplenomegaly -thrombocytopenia -microcephaly -severe mental retardation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

CMV is acquired from:

A

blood, tissue, and most bodily secretions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

CMV is the most prevalent cause of __

A

birth defects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

a reason for high rates of transmission of HSV1 and 2 is that there is the potential for __

A

asymptomatic shedding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

where does HSV-1 remain latent?

A

the trigeminal nerve ganglion

23
Q

persistent infection

A

in lymphocytes and macrophages

24
Q

Varicella Zoster primary infection:

A

chickenpox

25
lytic infection:
causes cell death and results in a sub/clinically apparent infection
26
treatments for HSV 1 and 2
Acyclovir Famciclovir Valacyclovir
27
the attack rate for chickenpox is \_\_
90%
28
other histology associated with CMV:
"Owl's eye" inclusion body
29
prodrome
the period leading up to the recurrence of an infection (could be pain or tingling)
30
ophthalmic zoster
virus resided within V1 and can cause corneal damage and vision loss
31
how does Herpes mature?
budding through the inner lamella of the nuclear membrane
32
antiviral treatments for VZV
acyclovir famcyclovir valacyclovir
33
CMV serious congenital infection occurs when the fetus is infected in the __ trimester. This only occurs during the __ infection
first, primary
34
\_\_ immunity controls and limits the spread of VZV
cellular mediated
35
zoster and HSV are spread by:
direct contact
36
herpes viruses are ubiquitous except:
HHV8
37
heterophile (monospot) positive mononucleosis is caused by:
EBV
38
Herpes virus assembles in the \_\_
nucleus
39
how are Acyclovir, Famciclovir, and Valacyclovir metabolized?
_viral_ thymidine kinase -- phosphorylates them to the monophosphate form, and cellular DNA polymerase adds di and tri phosphate forms
40
neonates have a \_\_% mortality rate following infection with VZV
35%
41
γ-herpesviruses
EBV, HHV-8
42
Zostavax
shingles vaccine, a weakened form of the chickenpox vaccine
43
smallpox lesions are \_\_
monomorphic
44
herpetic whitlow
herpes blisters on the fingers
45
transformation
infected cells survive and exhibit the ability to multiply and immortalize B lymphocytes -EBV and HHV-8 are associated with human cancers
46
the chickenpox vaccine is \_\_, and is \_\_% effective
live attenuated, 85%
47
how do we treat CMV?
ganciclovir and foscarnet (reduces viral shedding)
48
CMV in neonates:
cause no disease in healthy full-term babies, asymptomatic in most cases
49
\_\_ smear for HSV demonstrates ___ and \_\_
Tzanck, multi-nucleated giant cells and Cowdry type A inclusions bodies
50
which herpes viruses are latent?
Herpes I, II and varicella zoster
51
Abreva
10% docosanol- changes the membrane around healthy cells -used for oral herpes
52
how do HSVs avoid antibody?
cell to cell spread (syncytia)
53
3 antivirals for HSV 1 and 2 infections:
1. _Acyclovir_ 2. _Famcyclovir_ -- converted to pencyclovir. Improved bioavailability 3. _Valacyclovir_ -- aka Valtrex, L-valine ester of acyclovir. Improved bioavailability

MIM 2 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions