26. Antiulcer drugs and liver protectants

Question 1

Antiulcer drug groups

Answer 1

1. Acid neutralizers (antacids)
2. Acid secretion inhibitors
3. Drugs increasing mucosal resistance

Question 2

1. Acid neutralizers (antacids)

Answer 2

Systemic: 
NaHCO3 – baking soda
Non-systemic: 
MgO 
MgO 
Al(OH)3 
(these are used together)

Question 3

2. Acid secretion inhibitors

Answer 3

H2 antagonists:

• Cimetidine
• Ranitidine
• Famotidine

Proton pump inhibitors:

• Omeprazole
• pantoprazole

Question 4

3. Drugs increasing mucosal resistance

Answer 4

PGE-analogues:
Misoprostole

Coating agents:

• Sucralfate
• Sucrose octasulphate
• Al(OH)3 is antacid and coating

Question 5

Liver protectants

Answer 5

1. Cholagogues: cholekinetics and choleretics
2. Hepatoprotectants
3. Lipotropic agents

Question 6

1. Cholagogues: cholekinetics and choleretics

Answer 6

Cholekinetics: MgSO4
Choleretics: UDGA, menbutone, clanbutin

Question 7

2. Hepatoprotectants

Answer 7

Silymarin, silibinin

Question 8

3. Lipotropic agents

Answer 8

Choline
methionine
SAMe
D-penicillamin (chelator)

Other:
Glucose, fructose
NAC (N-acetyl-cysteine) antioxidant, antidote in paracetamol toxicosis
Vitamin E, Vitamin C, selenium