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Microbio > 26 Agents > Flashcards

26 Agents Flashcards

1
Q

DNA + RNA polymerase inhibitor
Oxphos inhibitor

Trypanosomiasis

A

Pentamidine

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2
Q

Aresnical that inhibits parasitic sulfyhydrl enzymes

Trypanosomiasis

A

Melarsoprol

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3
Q

IV
Inhibits polyamine biosynthesis, inhibits ornithine decarboxylase

Trypanosomiasis

A

Elfornithine

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4
Q

For T. Cruzii (Chagas)
Produces intracellular free radicals – kills the parasite

Trypanosomiasis

A

Nifurtimox

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5
Q

For Chagas Disease

Trypanosomiasis

A

Benzindazole

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6
Q

Inhibits glycolysis and TCA cycle.
Adverse Effects: Cardiac and pancreas problems

Leishmaniasis and PAM

A

Sodium Stibogluconate

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7
Q

Oral
MOA = binds to DNA and inhibits cytochrome C oxidase
Clincal Uses: Naegleria Fowleri (primary amoebic meningoencephalitis)

Leishmaniasis and PAM

A

Miltefosine

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8
Q

Binds to proteins and DNA
AE = disulfiram like reaction

Giardia Lamblia

A

METRONIDAZOLE

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9
Q

Amoebicidal, bactericidial, trichomonacidal
MOA = disrupts the tertiary structure of DNA and inhibits nucleic acid synthesis

Giardia Lamblia

A

TINIDAZOLE

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10
Q

Treatment for Trichomonas Vaginalis
Partner is ALSO treated even if not symptomatic

A

Metronidazole and Tinidazole

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11
Q

Asymptomatic carriers
AE = myelo-optic neuropathy

Entamoeba Histolytica

A

Iodoquinol (Luminal)

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12
Q

1st line for Amebiasis and Giardiasis in pregnancy

Entamoeba Histolytica

A

Paromomycin (Luminal)

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13
Q

IM: blockchain elongation proteins
CI = pregnancy
AE = cardiotoxicity
Used only when Patient does not respond and cant use metronidazole

Entamoeba Histolytica

A

Emetine and Dehydroemetine (systemic)

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14
Q

Long Term Use
**MOA = inhibits folate synthesis **
Leucovorin – admin to protect against folate deficency

Toxoplasmosis

A

Pyrimethamine and Sulfonamide

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15
Q

Lipophilic, oral, excreted in stool
MOA: Inhibits mitochondrial ETC
Clincal Use: Toxoplasmosis + PJP in AIDS patients

Toxoplasmosis

A

Atovaquone

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16
Q

MOA: Inhibits plasmodium heme polymerase, inserts into parasite DNA
Clinical Use = acute attacks/amebic systentery, RA, lupus
AE: retinal damage, ototoxicity, and visual disturbances

MALARIA DRUG

A

Chloroquine

17
Q

MOA: inhibits dihydrofolate reductase
Clincal Use = chloroquine resistant P. falciparum

MALARIA DRUG

A

Pyrimethamine

18
Q

MOA = damage to membrane
Clincal Use = resistant to P. falciparum

MALARIA DRUG

A

Mefloquine

19
Q

MOA: inhibit DNA replication, eradicates latent tissue and hepatic forms
Clincal - relapses of P vivax and Ovale
AE: Anemia in G6PDH deficency

Malaria Drug

A

Primaquine

20
Q

MOA = disrupts DNA synthesis
Clinical – resistant strains, asexual erythocyte forms, NOT active against exoerythrocytic forms

Malaria Drugs

A

Quinine

21
Q

MOA = inhibits DHF reductase
Clincal = prophylaxis – only in combo with atovaquone

Malaria Drug

A

Proguanil

22
Q

MOA = synergistic effect when used together
ETC and folate reductase inhibitors

Malaria Drugs

A

Atovaquone/proguanil

23
Q

MOA =** inhibit DNA replication and translation**
Synergistic effect prevent resistance
Clincal Use: HERB used in combo treatment of malaria resistant P. Falciparum

A

Artemether/lumefantrine

24
Q

MOA = inhibits microtubule synthesis – expelled in feces
Clincal Use: Roundworm, pinworm, hookworm, whipworm

Nematodes

A

Mebendazole and Albendazole

25
Q

MOA = depolarizing neruomuscular blocking agent, causes paralysis and release from intestinal wall
only effect in intestine

Nematodes

A

Pyrantel Pamoate

26
Q

Oral
MOA = binds to chloride channels = hyperpolarization, paralysis
Used for Onchocerciasis

Nematodes

A

Ivermectin

27
Q

effective against microfilariae NOT adult worms
MOA: Affects microfilariae membrane and musculature by hyperpolarization

Wichereria Bancrofti

A

Diethylcarbamazine

28
Q

MOA = inhibits ox phos and stimualtes ATPase
Admin w/ laxative to purge bowl

Cestodes

A

Nicolsamide

29
Q

Treats all species of trematodes and cestodes
MOA = increase Ca permeability of membrane = paralysis

A

Praziquantel

Microbio (4 decks)

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